The urokinase plasminogen activator (uPA) system (uPAS) consists of the uPA, its cognate
receptor (uPAR) and two specific inhibitors, the plasminogen activator inhibitor 1 (PAI-1) and …

Bioactive sphingolipids, such as ceramide, sphingosine and sphingosine-1-phosphate are
known bio-effector molecules which play important roles in various aspects of cancer …

Cholangiocarcinoma is an intractable cancer, with no effective therapy other than surgical
resection. Elevated vascular endothelial growth factor (VEGF) and epidermal growth factor …

The resorption, formation and maintenance of bone are coordinated by the action of several
hormones, growth factors and transcription factors. Recent experiments based on …

Prostate cancer represents a major health issue and its incidence is rising globally. In
developed countries, prostate cancer is the most frequently diagnosed cancer and the …

BACKGROUND Bone metastasis occurs frequently in advanced prostate cancer (PCa)
patients; however, it is not known why this happens. The epidermal growth factor receptor …

After prostate cancer cells (PCa) arrive in bone, interactions with cells that include long bone
osteoblasts (LBOB) and bone marrow stromal cells (BMSC) lead to metastasis formation …

Bone metastases in prostate cancer are predominantly osteoblastic. To study regulatory
mechanisms underlying the establishment of prostate cancer within an osteoblastic …

Purpose: Prostate cancer cell motility and invasion have been linked to the up-regulated
signaling of epidermal growth factor receptor and urokinase-type plasminogen activator …

The very early intuition of Paget about the molecular feature of metastasis has come in the
field of therapeutic opportunities only in the last few years with the development of targeted …