BACKGROUND: Eosinophils are key players in TH2-driven pathologies, such as allergic
lung inflammation. After IL-5–and eotaxin-mediated tissue recruitment, they release several …

Allergic diseases, such as allergic asthma, allergic rhinitis, atopic dermatitis, conjunctivitis,
urticaria, food allergy, and/or anaphylaxis, are associated with the skewing of immune …

BACKGROUND: The T cell–specific T-box transcription factor (TBX21) plays a crucial role in
the regulation of the immune system because this factor induces the differentiation of TH1 …

Background Airway remodeling is the specific pathological characteristics of asthma, which
is related to the clinical symptoms, pulmonary function, and airway hyperreactivity. This …

Controversy exists regarding the timing of the introduction of allergic foods into the diet. We
investigated the immune response of rat pups exposed to β-lactoglobulin (BLG), one of the …

CD8 T cells are known to deviate CD4 T-cell responses from Th2 toward Th1. Reduction of
Th2 cytokines and increased interferon-γ ameliorates allergic airway disease. We have …

BACKGROUND: A TH1-specific transcription factor, T-box–containing protein expressed in T
cells (T-bet), controls the production of both TH1 and TH2 cytokines in TH cell differentiation …

Studies of human asthma and of animal models of allergic airway inflammation revealed a
crucial role for Th2 cells in the pathogenesis of allergic asthma. Kruppel-type zinc finger …

Although Pneumocystis infection might be one of the causes of secondary pulmonary
alveolar proteinosis (PAP), the mechanism of its pathogenesis is uncertain. We analyzed a …