Histone modifying enzymes catalyze the addition or removal of an array of covalent
modifications in histone and non-histone proteins. Within the context of chromatin, these …

Since the publication of our previous Perspective dealing with polyamine drug discovery, 1
the field has undergone numerous changes. Most prominent among these changes, from a …

Acetylation is a well-studied posttranslational modification that has been associated with a
broad spectrum of biological processes, notably gene regulation. Many studies have …

We identified a series of 4-hydroxyquinolines bearing a C1 to C15 alkyl chain at the C2
position and a carbethoxy/carboxy group at the C3 position of the quinoline nucleus (MC …

Neurodegenerative disorders (NDs) such as Huntington's disease, Alzheimer's disease,
Parkinson disease, amyotrophic lateral sclerosis, spinal muscular atrophy, Friedreich's …

This report provides in vivo evidence for the posttranslational control of the acetyl coenzyme
A (Ac-CoA) synthetase (AcsA) enzyme of Bacillus subtilis by the acuA and acuC gene …

There is emerging recognition of a novel fuel and redox sensing regulatory program that
controls cellular adaptation via nonhistone protein lysine residue acetyl posttranslation …

Several epidemiological studies suggest that coffee drinking is inversely correlated with the
risk of development of liver fibrosis. However, a causal, mechanistic explanation has long …

Pituitary adenomas, which account for 15–20% of intracranial tumors, are associated with
significant morbidity and mortality, due in part, to hormone hypersecretion and mass effects …

Histone acetylation and methylation are linked to a variety of nuclear activities, most notably
transcriptional regulation. Both synergistic and antagonistic relationships between these two …