All cancers arise as a result of changes that have occurred in the DNA sequence of the
genomes of cancer cells. Over the past quarter of a century much has been learnt about …

The hypothesis that cancer is driven by tumour-initiating cells (popularly known as cancer
stem cells) has recently attracted a great deal of attention, owing to the promise of a novel …

Background A recent genomewide mutational analysis of glioblastomas (World Health
Organization [WHO] grade IV glioma) revealed somatic mutations of the isocitrate …

Detection and characterization of genomic structural variation are important for
understanding the landscape of genetic variation in human populations and in complex …

Cancer is a complex collection of distinct genetic diseases united by common hallmarks.
Here, we expand upon the classic hallmarks to include the stress phenotypes of …

Abstract The Pathway Interaction Database (PID, http://pid. nci. nih. gov) is a freely available
collection of curated and peer-reviewed pathways composed of human molecular signaling …

Purpose Unexpected mutations affecting the isocitrate dehydrogenase (IDH1) gene at
codon 132 have been found in 12% of glioblastomas. Patients and Methods IDH1 codon …

Motivation: The molecular complexity of a tumor manifests itself at the genomic, epigenomic,
transcriptomic and proteomic levels. Genomic profiling at these multiple levels should allow …

Glioblastoma multiforme (GBM) is a malignant astrocytoma of the central nervous system
associated with a median survival time of 15 months, even with aggressive therapy. This …

Human brain tumors appear to have a hierarchical cellular organization suggestive of a
stem cell foundation. In vitro expansion of the putative cancer stem cells as stable cell lines …