Bariatric surgery is the only effective treatment for patients with morbid obesity. This is no
solution to the present obesity pandemic however. Currently licensed non-surgical …

The gastrointestinal tract is the largest endocrine organ in the body. It secretes more than 20
different peptide hormones, which serve both a local regulatory function and provide a …

We report the efficacy of a new peptide with agonism at the glucagon and GLP-1 receptors
that has potent, sustained satiation-inducing and lipolytic effects. Selective chemical …

Summary 1 Introduction 2 Physiological mechanisms of satiation and satiety 2.1
Physiological mechanisms of satiation 2.1. 1 Gastric mechanisms of satiation 2.1. 2 Intestinal …

Oxyntomodulin (Oxm) is an intestinal peptide that inhibits food intake and body weight in
rodents and humans. These studies used peptide analogs to study aspects of structure and …

We have used manganese-enhanced magnetic resonance imaging (MEMRI) to show
distinct patterns of neuronal activation within the hypothalamus and brainstem of fasted mice …

The exceeding efforts in understanding the signals initiated by nutrients and hormones in
the central nervous system (CNS) to regulate glucose and energy homeostasis have largely …

Obesity is becoming the healthcare epidemic of this century. Bariatric surgery is the only
effective treatment for morbid obesity. Gut hormones are key players in the metabolic …

Our knowledge of the complex mechanisms underlying energy homeostasis has expanded
enormously in recent years. Food intake and body weight are tightly regulated by the …

Available anti-obesity pharmacotherapy options remain very limited. The development of
more effective drugs has become a priority. The potential strategies to achieve weight loss …