Early life stress (ELS) is expected to increase reactivity of the hypothalamic–pituitary–
adrenocortical (HPA) axis; however, several recent studies have shown diminished cortisol …

OBJETIVO: A meta deste artigo foi a de estudar as relações ente maus-tratos na infância e
psicopatologia no adulto, como reflexo de uma disfunção do eixo hipotálamo-pituitária …

BACKGROUND: The dexamethasone/corticotropin releasing hormone (Dex/CRH) test has
been proposed as a potential tool for identifying endophenotypes relevant to mood …

Context Childhood trauma appears to be a potent risk factor for chronic fatigue syndrome
(CFS). Evidence from developmental neuroscience suggests that early experience …

BACKGROUND: Variation in the corticotropin-releasing hormone receptor (CRHR1) gene
has been shown to interact with early life stress to predict adult depression. This study was …

BACKGROUND & AIMS: A history of early adverse life events (EALs) is associated with a
poorer outcome and higher levels of distress in adult patients with functional gastrointestinal …

BACKGROUND: Growing evidence suggests that the serotonin transporter polymorphism (5-
HTTLPR) interacts with adverse environmental influences to produce an increased risk for …

The long-term implications of sexual abuse in childhood or adolescence (CSA) have been
relatively well documented regarding attachment (disorganized attachment in childhood …

Exposure to childhood trauma may induce persistent changes in Hypothalamic-Pituitary-
Adrenal (HPA)-axis functioning even in the absence of current psychopathology. Because …

Negative childhood family environments have been associated with stress-related physical
and psychological health consequences across the lifespan. The present study examined …