Cystic fibrosis pulmonary guidelines: treatment of pulmonary exacerbations
The natural history of cystic fibrosis lung disease is one of chronic progression with
intermittent episodes of acute worsening of symptoms frequently called acute pulmonary …
intermittent episodes of acute worsening of symptoms frequently called acute pulmonary …
Immunologic aspects of chronic obstructive pulmonary disease
This review is an account of how pulmonary damage caused by cigarette smoke and other
environmental toxins can incite inflammatory and immunologic reactions that culminate in …
environmental toxins can incite inflammatory and immunologic reactions that culminate in …
Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials
PMA Calverley, KF Rabe, UM Goehring, S Kristiansen… - The Lancet, 2009 - thelancet.com
Background The phosphodiesterase-4 inhibitor roflumilast can improve lung function and
prevent exacerbations in certain patients with chronic obstructive pulmonary disease …
prevent exacerbations in certain patients with chronic obstructive pulmonary disease …
The pathology of chronic obstructive pulmonary disease
The pathogenesis of chronic obstructive pulmonary disease (COPD) is based on the innate
and adaptive inflammatory immune response to the inhalation of toxic particles and gases …
and adaptive inflammatory immune response to the inhalation of toxic particles and gases …
How cigarette smoke skews immune responses to promote infection, lung disease and cancer
MR Stämpfli, GP Anderson - Nature Reviews Immunology, 2009 - nature.com
A complex and multilayered immune defence system protects the host against harmful
agents and maintains tissue homeostasis. Cigarette smoke ex posure markedly impacts the …
agents and maintains tissue homeostasis. Cigarette smoke ex posure markedly impacts the …
Physical activity in patients with COPD
H Watz, B Waschki, T Meyer… - European Respiratory …, 2009 - Eur Respiratory Soc
The present study aimed to measure physical activity in patients with chronic obstructive
pulmonary disease (COPD) to: 1) identify the disease stage at which physical activity …
pulmonary disease (COPD) to: 1) identify the disease stage at which physical activity …
Adherence to inhaled therapy, mortality and hospital admission in COPD
Background: Little is known about adherence to inhaled medication in chronic obstructive
pulmonary disease (COPD) and the impact on mortality and morbidity. Methods: Data on …
pulmonary disease (COPD) and the impact on mortality and morbidity. Methods: Data on …
Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials
LM Fabbri, PMA Calverley, JL Izquierdo-Alonso… - The Lancet, 2009 - thelancet.com
Background Patients with chronic obstructive pulmonary disease (COPD) have few options
for treatment. The efficacy and safety of the phosphodiesterase-4 inhibitor roflumilast have …
for treatment. The efficacy and safety of the phosphodiesterase-4 inhibitor roflumilast have …
Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease
R Shaykhiev, A Krause, J Salit… - The Journal of …, 2009 - journals.aai.org
When exposed to a specific microenvironment, macrophages acquire either M1-or M2-
polarized phenotypes associated with inflammation and tissue remodeling, respectively …
polarized phenotypes associated with inflammation and tissue remodeling, respectively …
Screening for and early detection of chronic obstructive pulmonary disease
JB Soriano, J Zielinski, D Price - The Lancet, 2009 - thelancet.com
Chronic obstructive pulmonary disease (COPD) is a substantially underdiagnosed disorder,
with the diagnosis typically missed or delayed until the condition is advanced. Spirometry is …
with the diagnosis typically missed or delayed until the condition is advanced. Spirometry is …