Attenuated influenza virus vaccines with modified NS1 proteins

JA Richt, A García-Sastre - Vaccines for pandemic influenza, 2009 - Springer
The development of reverse genetics techniques allowing the rescue of influenza virus from
plasmid DNA has opened up the possibility of inserting mutations into the genome of this …

Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza

J Steel, AC Lowen, L Pena, M Angel… - Journal of …, 2009 - Am Soc Microbiol
Due to the high mortality associated with recent, widely circulating strains of H5N1 influenza
virus in poultry, the recurring introduction of H5N1 viruses from birds to humans, and the …

Bunyaviruses and the type I interferon system

RM Elliott, F Weber - Viruses, 2009 - mdpi.com
The family Bunyaviridae contains more than 350 viruses that are distributed throughout the
world. Most members of the family are transmitted by arthopods, and several cause disease …

From where did the 2009'swine-origin'influenza A virus (H1N1) emerge?

AJ Gibbs, JS Armstrong, JC Downie - Virology journal, 2009 - Springer
The swine-origin influenza A (H1N1) virus that appeared in 2009 and was first found in
human beings in Mexico, is a reassortant with at least three parents. Six of the genes are …

The NS1 protein of a human influenza virus inhibits type I interferon production and the induction of antiviral responses in primary human dendritic and respiratory …

K Haye, S Burmakina, T Moran, A García-Sastre… - Journal of …, 2009 - Am Soc Microbiol
The NS1 protein of the influenza A virus is a potent virulence factor that inhibits type I
interferon (IFN) synthesis, allowing the virus to overcome host defenses and replicate …

Comparison of efficacy of commercial one dose and two dose PCV2 vaccines using a mixed PRRSV–PCV2–SIV clinical infection model 2–3-months post vaccination

T Opriessnig, AR Patterson, DM Madson, N Pal… - Vaccine, 2009 - Elsevier
The study objectives were to compare the duration of immunity of commercially available,
one and two dose, killed porcine circovirus type 2 (PCV2) vaccines. Sixty, 3.5-week-old pigs …

Blocking interhost transmission of influenza virus by vaccination in the guinea pig model

AC Lowen, J Steel, S Mubareka, E Carnero… - Journal of …, 2009 - Am Soc Microbiol
Interventions aimed at preventing viral spread have the potential to effectively control
influenza virus in all age groups, thereby reducing the burden of influenza illness. For this …

Alpha-C-galactosylceramide as an adjuvant for a live attenuated influenza virus vaccine

SA Kopecky-Bromberg, KA Fraser, N Pica, E Carnero… - Vaccine, 2009 - Elsevier
There is a substantial need to develop better influenza virus vaccines that can protect
populations that are not adequately protected by the currently licensed vaccines. While live …

Experimental infection of pigs with the human 1918 pandemic influenza virus

HM Weingartl, RA Albrecht, KM Lager… - Journal of …, 2009 - Am Soc Microbiol
Swine influenza was first recognized as a disease entity during the 1918 “Spanish flu”
pandemic. The aim of this work was to determine the virulence of a plasmid-derived human …

Influenza A viruses with truncated NS1 as modified live virus vaccines: pilot studies of safety and efficacy in horses

TM Chambers, M Quinlivan, T Sturgill… - Equine veterinary …, 2009 - Wiley Online Library
Reasons for performing study: Three previously described NS1 mutant equine influenza
viruses encoding carboxyterminally truncated NS1 proteins are impaired in their ability to …