The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

Nitric oxide production in response to flow-dependent shear forces applied on the surface of
endothelial cells is a fundamental mechanism of regulation of vascular tone, peripheral …

Clinical studies have reported that the widely used antihyperglycemic drug metformin
significantly reduces cardiac risk factors and improves clinical outcomes in patients with …

Background—Some studies have shown that metformin activates AMP-activated protein
kinase (AMPK) and has a potent cardioprotective effect against ischemia/reperfusion injury …

AMP-activated protein kinase (AMPK), a phylogenetically conserved serine/threonine
protein kinase, has been proposed to function as a 'fuel gauge'to monitor cellular energy …

Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that also
modulates physiologic cell signaling pathways. MIF is expressed in cardiomyocytes and …

Diabetic cardiomyopathy is manifested by compromised systolic and diastolic function. This
study was designed to examine the role of advanced glycation endproduct (AGE) and AGE …

AMPK (AMP-activated protein kinase) is a heterotrimetric enzyme that is expressed in many
tissues, including the heart and vasculature, and plays a central role in the regulation of …

AMP-activated protein kinase (AMPK) has been postulated as a super-metabolic regulator,
thought to exert numerous effects on skeletal muscle function, metabolism, and enzymatic …

Background—Diabetes increases the morbidity/mortality of ischemic heart disease, but the
underlying mechanisms are incompletely understood. Deficiency of both AMP-activated …