The protozoan parasites Trypanosoma brucei and Trypanosoma cruzi are the causative
agents of African trypanosomiasis and Chagas disease, respectively. These are debilitating …

The accumulation of sequenced genomes has expanded the already sizeable population of
cysteine peptidases from parasites. Characterization of a few of these enzymes has ascribed …

Unusually for a eukaryote, genes transcribed by RNA polymerase II (pol II) in Trypanosoma
brucei are arranged in polycistronic transcription units. With one exception, no pol II …

Primary ciliary dyskinesia (PCD) is a genetically heterogeneous inherited disorder arising
from dysmotility of motile cilia and sperm. This is associated with a variety of ultrastructural …

The composition of the large, single, mitochondrion (mt) of Trypanosoma brucei was
characterized by MS (2‐D LC‐MS/MS and gel‐LC‐MS/MS) analyses. A total of 2897 …

A novel large multigene family was recently identified in the human pathogen Trypanosoma
cruzi, causative agent of Chagas disease, and corresponds to∼ 6% of the parasite diploid …

Background In contrast to the essentially fully assembled genome sequences of the
kinetoplastid pathogens Leishmania major and Trypanosoma brucei the assembly of the …

Background Most agriculturally important legumes fall within two sub-clades of the
Papilionoid legumes: the Phaseoloids and Galegoids, which diverged about 50 Mya. The …

Background Genome sequencing of Leishmania species that give rise to a range of disease
phenotypes in the host has revealed highly conserved gene content and synteny across the …

In the search for new therapeutics for the treatment of human African trypanosomiasis, many
potential drug targets in Trypanosoma brucei have been validated by genetic means, but …