Selective cytotoxicity of a bicyclic Ras inhibitor in cancer cells expressing K-RasG13D
Mutation of RAS genes is a critical event in the pathogenesis of different human tumors and
in some developmental disorders. Here we present an arabinose-derived bicyclic …
in some developmental disorders. Here we present an arabinose-derived bicyclic …
Differences in flexibility underlie functional differences in the Ras activators son of sevenless and Ras guanine nucleotide releasing factor 1
TS Freedman, H Sondermann, O Kuchment… - Structure, 2009 - cell.com
The Ras-specific nucleotide exchange factor Son of sevenless (Sos) is inactive without Ras
bound to a distal allosteric site. In contrast, the catalytic domain of Ras guanine nucleotide …
bound to a distal allosteric site. In contrast, the catalytic domain of Ras guanine nucleotide …
Amphetamine alters Ras-guanine nucleotide-releasing factor expression in the rat striatum in vivo
NK Parelkar, Q Jiang, XP Chu, ML Guo, LM Mao… - European journal of …, 2009 - Elsevier
Ras-guanine nucleotide-releasing factors (Ras-GRFs) are densely expressed in neurons of
the mammalian brain. As a Ras-specific activator predominantly concentrated at synaptic …
the mammalian brain. As a Ras-specific activator predominantly concentrated at synaptic …
Identification of novel RasGRF1 interacting partners by large-scale proteomic analysis
P Lavagni, M Indrigo, G Colombo, E Martegani… - Journal of molecular …, 2009 - Springer
The brain-specific Ras guanine nucleotide exchange factor RasGRF1 is a protein
harbouring a complex array of structural motifs. It contains a pleckstrin homology (PH1) …
harbouring a complex array of structural motifs. It contains a pleckstrin homology (PH1) …
[图书][B] Molecular basis of L-DOPA-induced dyskinesia: Studies on striatal signaling
E Santini - 2009 - search.proquest.com
Parkinson's disease (PD) is a neurological disorder characterized by tremor, rigidity and
bradykinesia. PD is caused by selective degeneration of the dopaminergic neurons, which …
bradykinesia. PD is caused by selective degeneration of the dopaminergic neurons, which …
Synthesis and biological characterization of new molecules pharnacologically active derived from natural compouds
A Palmioli - 2009 - boa.unimib.it
The inhibition of the oncogenic variants of Ras proteins represents an interesting and
promising research field for the development of new anticancer therapies. During this thesis …
promising research field for the development of new anticancer therapies. During this thesis …
RASGRF1 (Ras protein-specific guanine nucleotide-releasing factor 1)
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to
the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated …
the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated …