Post-translational degradation of protein plays an important role in cell life. We employed
chimeric molecules (dihydrotestosterone-based proteolysis-targeting chimeric molecule …

Mutational changes coupled with endocrine, paracrine, and/or autocrine signals regulate
cell division during carcinogenesis. The hormone signals remain undefined, although the …

BACKGROUND Compelling evidence has accumulated for chemopreventive effects for the
active component of green tea Epigallocatechin‐3‐Gallate (EGCG) particularly for prostate …

Prostate cancer in the dog (cPC) has many features in common with hormone refractory
human prostate cancer. As cPC is seen more often in castrated dogs, the contribution of the …

Androgens play a central role in prostate cancer pathogenesis, and hence most of the
patients respond to androgen deprivation therapies. However, patients tend to relapse with …

The targeted delivery of chemotherapeutics is essential to minimizing the side effects by
sparing the normal tissues by exposure to cytotoxic agents. The various receptors are …

目的探讨中药成分熊果酸对雄激素非依赖性前列腺癌(AIPC) 的治疗作用及其机制.
方法应用熊果酸处理体外培养的人雄激素依赖性前列腺癌(ADPC) 细胞株LNCaP 和AIPC …

The androgen receptor (AR) is critical in the initiation and progression of prostate cancer,
and therefore may contribute to disease through its genetic variation. Particular scrutiny has …

Currently, there are no preclinical immunocompetent mouse models that adequately
represent all stages of prostate cancer (PC) especially, androgen depletion independent …

Replication-selective adenoviruses are promising anti-cancer therapies (virotherapy).
Viruses can be engineered to selectively target cancer cells by deleting viral genes involved …