Calcium-induced calcium release (CICR) was first discovered in skeletal muscle. CICR is
defined as Ca2+ release by the action of Ca2+ alone without the simultaneous action of …

Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disease that affects boys and
leads to early death. In the quest for new treatments that improve the quality of life and in the …

Duchenne muscular dystrophy is characterized by progressive muscle weakness and early
death resulting from dystrophin deficiency. Loss of dystrophin results in disruption of a large …

It has long been known that skeletal muscle contraction persists in the absence of
extracellular Ca2+. Nevertheless, recent evidence indicates that multiple distinct Ca2+ entry …

Muscular dystrophies are among the most severe inherited muscle diseases. The genetic
defect is a mutation in the gene for dystrophin, a cytoskeletal protein which protects muscle …

Skeletal muscle function is dependent on its highly regular structure. In studies of dystrophic
(dy/dy) mice, the proportion of malformed myofibers decreases after prolonged whole …

In Duchenne muscular dystrophy, deficiency of the cytoskeletal protein dystrophin leads to
well-described defects in skeletal muscle, but also to dilated cardiomyopathy, accounting for …

In mammalian skeletal muscle, an intimate association between the sarcoplasmic reticulum
(SR) and mitochondria results in a symbiotic and privileged bidirectional communication …

The skeletal muscle contractile machine is fueled by both calcium and ATP. Calcium ions
activate the contractile machinery by binding to troponin C and relieving troponin …

Calcium sparks represent local, rapid, and transient calcium release events from a cluster of
ryanodine receptors (RyRs) in the sarcoplasmic reticulum. In arterial smooth muscle cells …