This review gives an account of recent advances in our knowledge of the molecular
mechanisms in colorectal cancer. Genetic changes in the germ line, combined with somatic …

Despite many studies of the likely survival outcome of individual patients with colorectal
cancer, our knowledge of this subject remains poor. Until recently, we had virtually no …

The normal functioning of p53 is a potent barrier to cancer. Tumour-associated mutations in
TP53, typically single nucleotide substitutions in the coding sequence, are a hallmark of …

To identify risk variants for childhood acute lymphoblastic leukemia (ALL), we conducted a
genome-wide association study of two case-control series, analyzing the genotypes with …

The common sequence variants that have recently been associated with cancer risk are
particular to a single cancer type or at most two. Following up on our genome-wide scan of …

Homozygosity for the G allele of rs6983267 at 8q24 increases colorectal cancer (CRC)
risk∼ 1.5 fold. We report here that the risk allele G shows copy number increase during …

Genome-wide association studies have recently identified ten common genetic variants
associated with colorectal cancer susceptibility, several suggesting the involvement of …

Background: Osteoporosis is a highly heritable trait. Many candidate genes have been
proposed as being involved in regulating bone mineral density (BMD). Few of these findings …

Germline mutations of the BRCA1 and BRCA2 genes confer a high life-time risk of ovarian
cancer. They represent the most significant and well characterised genetic risk factors so far …

Large interindividual variation is observed in both the response and toxicity associated with
anticancer therapy. The etiology of this variation is multifactorial, but is due in part to host …