Morbidity and mortality associated with viral infections increase with age, although the
underlying mechanisms are unclear. Here, we investigated whether aging alters …

Natural killer T (NKT) cells are known to produce Th17 cytokine IL-17 in addition to Th1/2
cytokines. In this study, the ability of NKT cells to produce IL-22, another Th17 cytokine, was …

Mouse type I natural killer T cell receptors (iNKT TCRs) use a single Vα14-Jα18 sequence
and Vβs that are almost always Vβ8. 2, Vβ7, or Vβ2, although the basis of this differential …

The molecular requirements for invariant Vα14-bearing natural killer T cells (iNKT) in the
thymus are poorly understood. A minute population of≈ 500 newly selected CD69+ CD24+ …

Purpose: Immunoregulatory and suppressive mechanisms represent major obstacles to the
success of immunotherapy in cancer patients. We have shown that the combination of …

CD1 molecules are a family of non-polymorphic, class I antigen-presenting glycoproteins,
which bind and present amphiphilic lipid antigens for recognition to T cells. Two groups of …

Activation of innate immunity is critical for vaccine development and immunotherapy,
through triggering antigen specific immune responses. Natural killer T (NKT) cells are a …

Caspase recruitment domain‐containing membrane‐associated guanylate kinase protein‐1
(CARMA1) is a critical component of the NF‐κB signaling cascade mediated by TCR …

Human invariant natural killer T cells (iNKT cells) are a unique population of T cells that
express an invariantly rearranged T-cell receptor (TCR) composed of TCRVα24 and …

C-glycoside analogues of α-galactosylceramide were shown to activate both human and
mouse invariant NKT (iNKT) cells. Among these analogues, GCK152, which has an aromatic …