Inhibition of transcription by platinum antitumor compounds
RC Todd, SJ Lippard - Metallomics, 2009 - academic.oup.com
Cisplatin, carboplatin, and oxaliplatin are three FDA-approved members of the platinum
anticancer drug family. These compounds induce apoptosis in tumor cells by binding to …
anticancer drug family. These compounds induce apoptosis in tumor cells by binding to …
Targeting the DNA damage response in cancer
M Ljungman - Chemical reviews, 2009 - ACS Publications
US general Ulysses S. Grant once said:“The art of war is simple enough. Find out where
your enemy is. Get at him as soon as you can. Strike him as hard as you can.” The decision …
your enemy is. Get at him as soon as you can. Strike him as hard as you can.” The decision …
Pharmacodynamic effects of seliciclib, an orally administered cell cycle modulator, in undifferentiated nasopharyngeal cancer
Purpose: Cell cycle dysregulation resulting in expression of antiapoptotic genes and
uncontrolled proliferation is a feature of undifferentiated nasopharyngeal carcinoma. The …
uncontrolled proliferation is a feature of undifferentiated nasopharyngeal carcinoma. The …
MET receptor tyrosine kinase as a therapeutic anticancer target
CM Stellrecht, V Gandhi - Cancer letters, 2009 - Elsevier
Tyrosine kinases are frequently deregulated in cancer either by constitutive activation,
mutation, or over-expression. Though they are often associated with an aggressive …
mutation, or over-expression. Though they are often associated with an aggressive …
Improving accuracy and precision in biological applications of fluorescence lifetime imaging microscopy
CW Chang - 2009 - search.proquest.com
The quantitative understanding of cellular and molecular responses in living cells is
important for many reasons, including identifying potential molecular targets for treatments of …
important for many reasons, including identifying potential molecular targets for treatments of …