How mitochondria produce reactive oxygen species

MP Murphy - Biochemical journal, 2009 - portlandpress.com
The production of ROS (reactive oxygen species) by mammalian mitochondria is important
because it underlies oxidative damage in many pathologies and contributes to retrograde …

The Randle cycle revisited: a new head for an old hat

L Hue, H Taegtmeyer - American Journal of Physiology …, 2009 - journals.physiology.org
In 1963, Lancet published a paper by Randle et al. that proposed a “glucose-fatty acid cycle”
to describe fuel flux between and fuel selection by tissues. The original biochemical …

Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins

KE Wong, FL Szeto, W Zhang, H Ye… - American journal …, 2009 - journals.physiology.org
Recent studies have established that vitamin D plays multiple biological roles beyond
calcium metabolism; however, whether vitamin D is involved in energy metabolism is …

[HTML][HTML] L-carnitine decreases DNA damage and improves the in vitro blastocyst development rate in mouse embryos

H Abdelrazik, R Sharma, R Mahfouz, A Agarwal - Fertility and sterility, 2009 - Elsevier
OBJECTIVE: To optimize the L-carnitine (LC) concentration as a supplement in embryo
culture medium and to investigate the effect of LC on developing embryos. DESIGN …

[HTML][HTML] Daily injection of tumor necrosis factor-α increases hepatic triglycerides and alters transcript abundance of metabolic genes in lactating dairy cattle

BJ Bradford, LK Mamedova, JE Minton… - The Journal of …, 2009 - Elsevier
To determine whether inflammation can induce bovine fatty liver, we administered
recombinant bovine tumor necrosis factor-α (rbTNF) to late-lactation Holstein cows. Cows …

The paradox of the carnitine palmitoyltransferase type Ia P479L variant in Canadian Aboriginal populations

CR Greenberg, LA Dilling, GR Thompson… - Molecular genetics and …, 2009 - Elsevier
Investigation of seven patients from three families suspected of a fatty acid oxidation defect
showed mean CPT-I enzyme activity of 5.9±4.9 percent of normal controls. The families, two …

An overview of beta-oxidation disorders.

D Moczulski, I Majak, D Mamczur - Postepy higieny i medycyny …, 2009 - europepmc.org
Fatty acids (FAs) are components of cell membrane, enzymes, and hormones and are one of
the most important energy sources for many organisms. There are several types of fatty-acid …

Hypermetabolism, hyperphagia, and reduced adiposity in tankyrase-deficient mice

TYJ Yeh, KK Beiswenger, P Li, KE Bolin, RM Lee… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE Tankyrase (TNKS) is a Golgi-associated poly-ADP-ribose polymerase that is
implicated in the regulation of GLUT4 trafficking in 3T3-L1 adipocytes. Its chromosomal …

Muscle acylcarnitines during short-term fasting in lean healthy men

MR Soeters, HP Sauerwein, M Duran… - Clinical …, 2009 - portlandpress.com
The transition from the fed to the fasted resting state is characterized by, among other things,
changes in lipid metabolism and peripheral insulin resistance. Acylcarnitines have been …

3,5-Diiodo-l-thyronine rapidly enhances mitochondrial fatty acid oxidation rate and thermogenesis in rat skeletal muscle: AMP-activated protein kinase involvement

A Lombardi, P de Lange, E Silvestri… - American Journal …, 2009 - journals.physiology.org
Triiodothyronine regulates energy metabolism and thermogenesis. Among triiodothyronine
derivatives, 3, 5-diiodo-l-thyronine (T2) has been shown to exert marked effects on energy …