G-protein receptor kinases (GRKs) are indispensable for terminating signaling of G-protein
coupled receptors (GPCR) through receptor desensitization and downregulation. Increased …

The termination of heptahelical receptor signaling is a multilevel process coordinated, in
large part, by members of the arrestin family of proteins. Arrestin binding to agonist-occupied …

The C957T polymorphism of the human dopamine D2 receptor gene (DRD2) regulates
DRD2 availability in striatum in vivo. Specifically, the T allele predicts high DRD2 availability …

We investigated the role of G protein-coupled receptor kinase (GRK)-mediated
phosphorylation in agonist-induced desensitization, arrestin association, endocytosis, and …

Dopamine (DA) plays crucial roles in the cognitive functioning of the prefrontal cortex (PFC),
which, to a large degree, depends on lasting neural traces formed in prefrontal networks …

The dopaminergic system plays an important role in the etiology of schizophrenia, and most
antipsychotic drugs exert their functions by blocking dopamine D2 receptors (D2Rs). Since …

Wnt ligands conduct their functions in canonical Wnt signaling by binding to two receptors,
the single transmembrane low density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) …

G protein-coupled receptor kinase 5 (GRK5) deficiency has been linked recently to early
Alzheimer disease (AD), but the mechanism by which GRK5 deficiency may contribute to AD …

Oxytocin plays an important role in the progression, timing, and modulation of uterine
contraction during labor and is widely used as an uterotonic agent. We investigated the …

G protein-coupled receptor kinases (GRKs) are a family of intracellular proteins that
desensitize and regulate the responsiveness of G protein-coupled receptors (GPCRs). In the …