The chemokine CCL20 and its receptor CCR6 in human malignancy with focus on colorectal cancer

P Ghadjar, C Rubie, DM Aebersold… - International journal of …, 2009 - Wiley Online Library
Chemokines are a superfamily of small chemotactic cytokines, which interact with their G‐
protein‐coupled receptors. These interactions regulate multiple physiological functions …

CC chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

A Reboldi, C Coisne, D Baumjohann, F Benvenuto… - Nature …, 2009 - nature.com
Interleukin 17–producing T helper cells (T H-17 cells) are important in experimental
autoimmune encephalomyelitis, but their route of entry into the central nervous system …

Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history

CW Lees, J Satsangi - Expert review of gastroenterology & …, 2009 - Taylor & Francis
Epidemiological data, detailed molecular studies and recent genome-wide association
studies strongly suggest that ulcerative colitis (UC) and Crohn's disease (CD) are related …

[图书][B] Wintrobe's clinical hematology

MM Wintrobe - 2009 - books.google.com
Now available in a thoroughly revised Twelfth Edition, Wintrobe's Clinical Hematology
continues to be an industry leader with its ability to correlate basic science with the clinical …

[HTML][HTML] The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut

C Wang, SG Kang, J Lee, Z Sun, CH Kim - Mucosal immunology, 2009 - Elsevier
Migration and trafficking receptors of Th17 cells to mucosal tissues have been unclear. We
report that Th17 cells preferentially migrate to the intestine and associated lymphoid tissues …

CCR6 is required for IL-23–induced psoriasis-like inflammation in mice

MN Hedrick, AS Lonsdorf… - The Journal of …, 2009 - Am Soc Clin Investig
Psoriasis is a common immune-mediated chronic inflammatory skin disorder, but the
mechanisms of pathogenesis are still poorly understood. IL-23 is expressed in psoriatic skin …

Inhibition of CCR6 function reduces the severity of experimental autoimmune encephalomyelitis via effects on the priming phase of the immune response

A Liston, RE Kohler, S Townley… - The Journal of …, 2009 - journals.aai.org
Chemokines are essential for homeostasis and activation of the immune system. The
chemokine ligand/receptor pairing CCL20/CCR6 is interesting because these molecules …

Contribution of Flagellin Pattern Recognition to Intestinal Inflammation during Salmonella enterica Serotype Typhimurium Infection

SE Winter, P Thiennimitr, SP Nuccio… - Infection and …, 2009 - Am Soc Microbiol
Salmonella enterica serotype Typhimurium causes acute inflammatory diarrhea in humans.
Flagella contribute to intestinal inflammation, but the mechanism remains unclear since most …

[HTML][HTML] Human Th17 cells in infection and autoimmunity

F Sallusto, A Lanzavecchia - Microbes and Infection, 2009 - Elsevier
IL-17-producing T cells (Th17) have been identified in mice as a distinct lineage of CD4+ T
helper cells. Since their discovery, efforts have been made in characterizing human Th17 …

Macrophage inflammatory protein-3alpha plays a key role in the inflammatory cascade in rat focal cerebral ischemia

Y Terao, H Ohta, A Oda, Y Nakagaito, Y Kiyota… - Neuroscience …, 2009 - Elsevier
Although hypothermia is one of the most robust neuroprotectants clinically available, its
underlying mechanisms remain unclear. Through microarray gene expression analysis, we …