Beyond their fundamental role in energy metabolism, mitochondria perform a great variety of
other important cellular functions. However, the interplay among these various roles of …

Recent advances in mitochondrial imaging have revealed that in many cells mitochondria
can be highly dynamic. They can undergo fission/fusion processes modulated by various …

BACKGROUND: Desmin-related myopathy is a clinically heterogenous group of disorders
encompassing myopathies, cardiomyopathies, conduction disease, and combinations of …

Ca2+ signaling is of vital importance to cardiac cell function and plays an important role in
heart failure. It is based on sarcolemmal, sarcoplasmic reticulum and mitochondrial Ca2+ …

The arrangement and movements of mitochondria were quantitatively studied in adult rat
cardiomyocytes and in the cultured continuously dividing non beating NB HL-1 cells with …

Mitochondria can be isolated from skeletal muscle in a manner that preserves tightly
coupled bioenergetic function in vitro. The purpose of this study was to characterize the …

Myofibrillar myopathies (MFMs) are rare inherited or sporadic progressive neuromuscular
disorders with considerable clinical and genetic heterogeneity. In the current study, we have …

We live in times of paradigmatic changes for the biological sciences. Reductionism, that for
the last six decades has been the philosophical basis of biochemistry and molecular …

In skeletal muscle, the sarcomeric α-actinins (α-actinin-2 and-3) are a major component of
the Z-line and crosslink actin thin filaments to maintain the structure of the sarcomere. Based …

Abstract The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, simvastatin, is
used for lowering elevated low-density lipoprotein cholesterol concentrations. This …