The role of PPARα in lipid metabolism and obesity: focusing on the effects of estrogen on PPARα actions

M Yoon - Pharmacological Research, 2009 - Elsevier
Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor that belongs to the steroid hormone receptor superfamily. PPARα is expressed …

Regulation of skeletal muscle physiology and metabolism by peroxisome proliferator-activated receptor δ

E Ehrenborg, A Krook - Pharmacological reviews, 2009 - ASPET
Agonists directed against the α and γ isoforms of the peroxisome proliferator-activated
receptors (PPARs) have become important for the respective treatment of …

[图书][B] Молекулярная генетика спорта. Монография

ИИ Ахметов - 2009 - elibrary.ru
Предлагаемая читателю монография–одна из первых попыток систематизации
накопленной к настоящему времени информации в области молекулярной генетики …

Comparative analysis of gene regulation by the transcription factor PPARα between mouse and human

M Rakhshandehroo, G Hooiveld, M Müller, S Kersten - PloS one, 2009 - journals.plos.org
Background Studies in mice have shown that PPARα is an important regulator of hepatic
lipid metabolism and the acute phase response. However, little information is available on …

Review of the expression of peroxisome proliferator-activated receptors alpha (PPARα), beta (PPARβ), and gamma (PPARγ) in rodent and human development

BD Abbott - Reproductive toxicology, 2009 - Elsevier
The peroxisome proliferator-activated receptors (PPAR) belong to the nuclear hormone
receptor superfamily and there are three primary subtypes, PPARα, β, and γ. These …

Untargeted metabolomic profiling as an evaluative tool of fenofibrate-induced toxicology in Fischer 344 male rats

T Ohta, N Masutomi, N Tsutsui, T Sakairi… - Toxicologic …, 2009 - journals.sagepub.com
Peroxisome proliferator-activated receptor-α (PPARα) agonists such as fenofibrate are used
to treat dyslipidemia. Although fenofibrate is considered safe in humans, it is known to cause …

PPAR‐gamma‐mediated neuroprotection in a chronic mouse model of Parkinson's disease

N Schintu, L Frau, M Ibba, P Caboni… - European Journal of …, 2009 - Wiley Online Library
Rosiglitazone is a commonly prescribed insulin‐sensitizing drug with a selective agonistic
activity on the peroxisome proliferator‐activated receptor‐gamma (PPAR‐γ). PPAR‐γ can …

Significance of peroxisome proliferator-activated receptors in the cardiovascular system in health and disease

E Robinson, DJ Grieve - Pharmacology & therapeutics, 2009 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear
transcription factors that belong to the nuclear receptor superfamily. Three isoforms of PPAR …

PPARδ agonism activates fatty acid oxidation via PGC-1α but does not increase mitochondrial gene expression and function

S Kleiner, V Nguyen-Tran, O Baré, X Huang… - Journal of Biological …, 2009 - ASBMB
PPARδ (peroxisome proliferator-activated receptor δ) is a regulator of lipid metabolism and
has been shown to induce fatty acid oxidation (FAO). PPARδ transgenic and knock-out mice …

Tie2-mediated loss of peroxisome proliferator-activated receptor-γ in mice causes PDGF receptor-β-dependent pulmonary arterial muscularization

C Guignabert, CM Alvira, TP Alastalo… - … of Physiology-Lung …, 2009 - journals.physiology.org
Peroxisome proliferator-activated receptor (PPAR)-γ is reduced in pulmonary arteries (PAs)
of patients with PA hypertension (PAH), and we reported that deletion of PPARγ in smooth …