Pharmacogenomics in aspirin intolerance

JAG Agundez, C Martinez, D Perez-Sala… - Current Drug …, 2009 - ingentaconnect.com
Polymorphisms in drug-related enzymes and receptors are often strongly related to altered
drug response and to the risk of developing drug intolerance. Aspirin, usually available as …

Molecular genetics of atherosclerosis

H Roy, S Bhardwaj, S Yla-Herttuala - Human genetics, 2009 - Springer
Atherosclerosis is a complex multifocal arterial disease involving interactions of multiple
genetic and environmental factors. Advances in techniques of molecular genetics have …

Current evidence for a modulation of low back pain by human genetic variants

I Tegeder, J Lötsch - Journal of cellular and molecular …, 2009 - Wiley Online Library
Introduction• Genetic polymorphisms associated with intervertebral disc disease (IDD)•
Polymorphisms in pro‐inflammatory genes• Polymorphisms associated with subtle …

Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke

RN Lemaitre, K Rice, K Marciante, JC Bis, TS Lumley… - Atherosclerosis, 2009 - Elsevier
OBJECTIVES: Eicosanoids are lipid mediators that may play a role in atherosclerosis. We
investigated the association of common genetic variation in prostaglandin H synthase 1 …

The genomic basis of cerebral palsy: a HuGE systematic literature review

ME O'Callaghan, AH MacLennan, EA Haan, G Dekker… - Human genetics, 2009 - Springer
Cerebral palsy has been associated with a number of candidate genes. To date, no
systematic review has been conducted to synthesise genetic polymorphism associations …

Plasma levels of matrix metalloproteinase-9 are independently associated with psychosocial factors in a middle-aged normal population

P Garvin, L Nilsson, J Carstensen… - Psychosomatic …, 2009 - journals.lww.com
Objective: To test the association between psychosocial factors and circulating levels of
matrix metalloproteinase-9 (MMP-9) in a normal population sample. Psychosocial factors …

[HTML][HTML] Polymorphisms cyclooxygenase-2-765G> C and interleukin-6-174G> C are associated with serum inflammation markers in a high cardiovascular risk …

D Corella, JI González, M Bulló, P Carrasco… - The Journal of …, 2009 - Elsevier
Inflammation is involved in cardiovascular diseases. Some studies have found that the
Mediterranean diet (MD) can reduce serum concentrations of inflammation markers …

Cyclooxygenase and prostaglandin synthases: roles in plaque stability and instability in humans

D Santovito, A Mezzetti, F Cipollone - Current opinion in lipidology, 2009 - journals.lww.com
Cyclooxygenase and prostaglandin synthases: roles in plaque... : Current Opinion in Lipidology
Cyclooxygenase and prostaglandin synthases: roles in plaque stability and instability in …

Effect of COX2 -765G>C and c.3618A>G polymorphisms on the risk and survival of sporadic colorectal cancer

D Iglesias, N Nejda, MM Azcoita, S Schwartz… - Cancer Causes & …, 2009 - Springer
Background The COX2 gene (also known as PTGS2) encodes one of the essential
cyclooxygenases for the prostanoid synthesis, and its expression is tightly regulated at both …

Omega‐3 Polyunsaturated Fatty Acids (n‐3 PUFAs) in Cardiovascular Diseases (CVDs) and Depression: The Missing Link?

JPC Chang, YT Chen, KP Su - Cardiovascular psychiatry and …, 2009 - Wiley Online Library
Background. Based on epidemiological data, clinical trials, and meta‐analytic reviews,
omega‐3 polyunsaturated fatty acids (n‐3 PUFAs) seem to be a biological link between …