Neurodegenerative diseases are progressive disorders of the nervous system that affect
specific cellular populations in the central and peripheral nervous systems. Although most …

One of the current problems in medicine research is the development of safe drugs for the
treatment of neurological disorders. Furthermore, there is a close relationship between the …

Hyperphosphorylation of tau at multiple sites has been implicated in the formation of
neurofibrillary tangles in Alzheimer's disease; however, the relationship between toxicity and …

Sirtuin 1 is a member of the sirtuin family of protein deacetylases, which have attracted
considerable attention as mediators of lifespan extension in several model organisms …

Various age‐related neurodegenerative diseases, including Parkinson's disease,
polyglutamine expansion diseases and Alzheimer's disease, are associated with the …

Histone deacetylases (HDACs) are a family of proteins that play an important role in
regulating transcription as well as the function of a variety of cellular proteins. While these …

Polyglutamine diseases are a class of inherited neurodegenerative disorders, characterized
by expansion of CAG trinucleotide repeats translated into elongated glutamine tracts within …