Polymorphism of human cytochrome P450 enzymes and its clinical impact
Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …
specific genes affect drug response. This article highlights current pharmacogenetic …
Role of interleukin-6 in the anemia of chronic disease
DSC Raj - Seminars in arthritis and rheumatism, 2009 - Elsevier
OBJECTIVES: To review evidence supporting the involvement of interleukin-6 in the
pathophysiology of anemia of chronic disease, to discuss the possible molecular …
pathophysiology of anemia of chronic disease, to discuss the possible molecular …
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects
LR Treviño, N Shimasaki, W Yang… - Journal of Clinical …, 2009 - ascopubs.org
Purpose Methotrexate plasma concentration is related to its clinical effects. Our aim was to
identify the genetic basis of interindividual variability in methotrexate pharmacokinetics in …
identify the genetic basis of interindividual variability in methotrexate pharmacokinetics in …
Flavonol-rich RVHxR from Rhus verniciflua Stokes and its major compound fisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthritic …
JD Lee, JE Huh, GS Jeon, HR Yang, HS Woo… - International …, 2009 - Elsevier
Rheumatoid arthritis (RA) is an aggressive inflammatory disease in which
cytokines/chemokines are thought to recruit leukocytes and induce angiogenesis. The aim of …
cytokines/chemokines are thought to recruit leukocytes and induce angiogenesis. The aim of …
Therapeutic potential of splice-switching oligonucleotides
J Bauman, N Jearawiriyapaisarn, R Kole - Oligonucleotides, 2009 - liebertpub.com
Alternative splicing enables a single pre-messenger RNA transcript to yield multiple protein
isoforms, making it a major contributor to the diversity of the proteome. While this process is …
isoforms, making it a major contributor to the diversity of the proteome. While this process is …
Epitope‐specific immunotherapy of rheumatoid arthritis: clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules …
EC Koffeman, M Genovese, D Amox… - … : Official Journal of …, 2009 - Wiley Online Library
Objective Induction of immune tolerance to maintain clinical control with a minimal drug
regimen is a current research focus in rheumatoid arthritis (RA). Accordingly, we are …
regimen is a current research focus in rheumatoid arthritis (RA). Accordingly, we are …
[HTML][HTML] Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds
X Deng, R Gujjar, F El Mazouni, W Kaminsky… - Journal of Biological …, 2009 - ASBMB
Malaria remains a major global health burden and current drug therapies are compromised
by resistance. Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) was …
by resistance. Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) was …
Clusterin: A multifacet protein at the crossroad of inflammation and autoimmunity
G Falgarone, G Chiocchia - Advances in cancer research, 2009 - Elsevier
For years, clusterin has been recognized as a secreted protein and a large number of works
demonstrated that this ubiquitously expressed protein has multiple activities. Among the …
demonstrated that this ubiquitously expressed protein has multiple activities. Among the …
Biochemical markers and the FDA Critical Path: how biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for …
The aim of this review is to discuss the potential usefulness of a novel class of biochemical
markers, neoepitopes, in the context of the US Food and Drug Administration (FDA) Critical …
markers, neoepitopes, in the context of the US Food and Drug Administration (FDA) Critical …
[HTML][HTML] CTLA4-Ig interacts with cultured synovial macrophages from rheumatoid arthritis patients and downregulates cytokine production
Introduction Co-stimulatory signal B7 (CD80/CD86): CD28 is needed in order to activate T
cells in immune response. Cytotoxic T lymphocyte-associated antigen-4-immunoglobulin …
cells in immune response. Cytotoxic T lymphocyte-associated antigen-4-immunoglobulin …