Hydrogels in regenerative medicine

BV Slaughter, SS Khurshid, OZ Fisher… - Advanced …, 2009 - Wiley Online Library
Hydrogels, due to their unique biocompatibility, flexible methods of synthesis, range of
constituents, and desirable physical characteristics, have been the material of choice for …

Growth factors, matrices, and forces combine and control stem cells

DE Discher, DJ Mooney, PW Zandstra - Science, 2009 - science.org
Stem cell fate is influenced by a number of factors and interactions that require robust control
for safe and effective regeneration of functional tissue. Coordinated interactions with soluble …

Engineered microenvironments for controlled stem cell differentiation

JA Burdick, G Vunjak-Novakovic - Tissue Engineering Part A, 2009 - liebertpub.com
In a developing organism, tissues emerge from coordinated sequences of cell renewal,
differentiation, and assembly that are orchestrated by spatial and temporal gradients of …

Influence of three-dimensional hyaluronic acid microenvironments on mesenchymal stem cell chondrogenesis

C Chung, JA Burdick - Tissue Engineering Part A, 2009 - liebertpub.com
Mesenchymal stem cells (MSCs) are multipotent progenitor cells whose plasticity and self-
renewal capacity have generated significant interest for applications in tissue engineering …

Self-assembled hyaluronic acid nanoparticles as a potential drug carrier for cancer therapy: synthesis, characterization, and in vivo biodistribution

KY Choi, KH Min, JH Na, K Choi, K Kim… - Journal of Materials …, 2009 - pubs.rsc.org
To develop a nano-sized drug delivery system for cancer therapy, amphiphilic hyaluronic
acid conjugates were synthesized by chemical conjugation of hydrophobic 5β-cholanic acid …

Engineering the embryoid body microenvironment to direct embryonic stem cell differentiation

AM Bratt‐Leal, RL Carpenedo… - Biotechnology …, 2009 - Wiley Online Library
Embryonic stem cells (ESCs) are pluripotent cells capable of differentiating into all somatic
and germ cell types. The intrinsic ability of pluripotent cells to generate a vast array of …

Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue

DR Davis, Y Zhang, RR Smith, K Cheng, J Terrovitis… - PloS one, 2009 - journals.plos.org
Background At least four laboratories have shown that endogenous cardiac progenitor cells
(CPCs) can be grown directly from adult heart tissue in primary culture, as cardiospheres or …

Layer‐by‐layer films as a biomimetic reservoir for rhBMP‐2 delivery: controlled differentiation of myoblasts to osteoblasts

T Crouzier, K Ren, C Nicolas, C Roy, C Picart - Small, 2009 - Wiley Online Library
Efficient delivery of growth or survival factors to cells is one of the most important long‐term
challenges of current cell‐based tissue engineering strategies. The extracellular matrix acts …

Generation of human embryonic stem cell‐derived mesoderm and cardiac cells using size‐specified aggregates in an oxygen‐controlled bioreactor

S Niebruegge, CL Bauwens, R Peerani… - Biotechnology and …, 2009 - Wiley Online Library
The ability to generate human pluripotent stem cell‐derived cell types at sufficiently high
numbers and in a reproducible manner is fundamental for clinical and biopharmaceutical …

Mechanically robust and bioadhesive collagen and photocrosslinkable hyaluronic acid semi-interpenetrating networks

MD Brigham, A Bick, E Lo, A Bendali… - … Engineering Part A, 2009 - liebertpub.com
In this work, we present a class of hydrogels that leverage the favorable properties of the
photo-cross-linkable hyaluronic acid (HA) and semi-interpenetrating collagen components …