The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …

The endocannabinoid signalling system includes:(1) at least two G-protein-coupled
receptors, known as the cannabinoid CB1 and CB2 receptors and discovered following …

The endocannabinoids anandamide and 2-arachidonoylglycerol are lipid mediators that
signal via CB1 and CB2 cannabinoid receptors and Gi/o-proteins to inhibit adenylyl cyclase …

Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) were the first endocannabinoids to
be characterized, that bind two G protein-coupled receptors, CB1 and CB2. AEA synthesized …

Since the first suffering supplicant offered a prayer to his god or the first mother cradled an
ailing child in her caring arms, we have witnessed how human health and healing goes …

Endocannabinoids and endovanilloids are, by definition, endogenous agonists at
cannabinoid CB1 or CB2 receptors and transient receptor potential vanilloid-type-1 (TRPV1) …

Cannabinoid system plays a pivotal role in the seizure threshold modulation which is mainly
mediated through activation of the cannabinoid CB1 receptor. There is also several …

The neuromodulatory effects of cannabinoids in the central nervous system have mainly
been associated with G-protein coupled cannabinoid receptor (CB1R) mediated inhibition of …

Marijuana is the most commonly used illicit drug. Although there is some indication that
reproductive functions in males are impaired in chronic marijuana users, the genetic …

Background Neurons in superficial (SDH) and deep (DDH) laminae of the spinal cord dorsal
horn receive sensory information from skin, muscle, joints and viscera. In both regions …