A large proportion of hemophilia A patients who receive replacement therapy, develop an
immune response toward the infused factor VIII (FVIII). In this review, we discuss recent …

B cells are major players in T1D in humans, and clearly essential for disease development
in the NOD mouse model of T1D. In this review, we discuss the silencing of autoreactive B …

Type 1 diabetes results from T cell-mediated destruction of insulin-producing β cells.
Although elimination of B lymphocytes has proven successful at preventing disease …

Self-reactive B lymphocytes play two main pathological roles in autoimmune diseases: as
secretors of autoantibodies and as specialized antigen-presenting cells that present self …

B cells play an important role in the pathogenesis of both systemic and organ-specific
autoimmune diseases. Autoreactive B cells not only produce autoantibodies, but are also …

BACKGROUND: B cell depletion has been employed to treat antibody-mediated organ
transplantation rejection, although the effects on cellular immune responses have not been …

Immunomodulation of self-antigen presentation by professional antigen presenting cells
might hold therapeutic promise in the treatment of autoimmune diseases. The spleen …

Cell therapy represents an increasingly promising approach for the cure of many chronic
and degenerative disorders, such as type 1 (insulin-dependent) diabetes mellitus and …

The constant threat of microbial invasion and pathogenesis forces the host to depend on a
powerful army: the immune system. Whereas innate immunity provides rapid protection …

ABSTRACT Type 1 Diabetes (T1D) is an autoimmune disease where the immune system
destroys the insulin-producing β cells within the pancreas. Due to the difficulty of obtaining …