In eukaryotic cells, the physical separation of the genetic material in the nucleus from the
translation and signaling machinery in the cytoplasm by the nuclear envelope creates a …

A primary failsafe program against unrestrained proliferation and oncogenesis is provided
by the p53 tumor suppressor protein, inactivation of which is considered as a hallmark of …

Background Insulin-like growth factor binding protein 5 (IGFBP5) has been shown to be
associated with breast cancer metastasis in clinical marker studies. However, a major …

Hepatocellular carcinoma (HCC) ranks in prevalence and mortality among top 10 cancers
worldwide. Butyric acid (BA), a member of histone deacetylase inhibitors (HDACi) has been …

On the northeastern coast of the United States and Canada, Mya arenaria, the soft shell
clam, develops a diffuse, hemopoetic tumor (a fatal leukemia-like cancer) resulting from …

Purpose: Galanin and its three receptors (GALR1-3) are expressed in many normal tissues,
but silenced in some tumors. Contradictory roles for galanin and its receptors in various …

The mdm2 and mdmx oncogenes play essential yet nonredundant roles in synergistic
inactivatiosn of p53. However, the biochemical mechanism by which Mdmx synergizes with …

Previous studies have described one nuclear localization signal (NLSI) in p53 and
speculated on two additional sites termed NLSII and NLSIII. Drug-resistant KB cells selected …

The tightly regulated expression of p53 contributes to genomic stability and transcription of
the p53 gene is induced prior to cells entering S-phase, possibly as a mechanism to insure a …

The p53 homologue p73 is overexpressed in many tumors, including lung cancer. We have
evaluated the differential expression and subcellular localization of the functionally distinct …