Drug transporters are recognized as key players in the processes of drug absorption,
distribution, metabolism, and elimination. The localization of uptake and efflux transporters …

In vitro data on the metabolism of the antifungal voriconazole suggest that its
pharmacokinetics might be influenced by the activity of CYP2C19, CYP2C9, and CYP3A. To …

Applications of omics technologies in the postgenomics era swiftly expanded from rare
monogenic disorders to multifactorial common complex diseases, pharmacogenomics, and …

Objectives The objective of this study was to compare atazanavir pharmacokinetics in
genetically determined CYP3A5 expressors versus non-expressors. Methods HIV-negative …

Aims: The cholesterol-lowering drug simvastatin is a substrate for P-glycoprotein (P-gp). P-
gp, encoded by ABCB1, is an efflux transporter and genetic variation in ABCB1 is associated …

Abstract BACKGROUND: Tobacco‐specific nitrosamine 4‐(methylnitrosamino)‐1‐(3‐
pyridyl)‐1‐butanone (NKK) is a well defined carcinogen that can induce lung cancer …

Personalized, or genomic, medicine entails tailoring pharmacological therapies according to
individual genetic variation at genomic loci encoding proteins in drug-response pathways. It …

目的: 探讨多药耐药基因MDR1 C3435T (exon 26) 位点基因多态性对替米沙坦在原发性高血压
患者中的稳态血药浓度及降压疗效的影响. 方法: 采用聚合酶链反应(PCR) …

The ATP-binding cassette (ABC) proteins represent a highly diversified superfamily in all
living kingdoms, with 49 human proteins, 14 of which are associated with various diseases …

This review presents the published data regarding the molecular determinants (enzymes,
transporters, orphan nuclear receptors) of fluoroquinolones pharmacokinetics in humans …