Mouse models for the study of colon carcinogenesis
The study of experimental colon carcinogenesis in rodents has a long history, dating back
almost 80 years. There are many advantages to studying the pathogenesis of carcinogen …
almost 80 years. There are many advantages to studying the pathogenesis of carcinogen …
[图书][B] Translational pain research: from mouse to man
L Kruger, AR Light - 2009 - taylorfrancis.com
One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of
molecular biology and the new tools derived from molecular genetics have revolutionized …
molecular biology and the new tools derived from molecular genetics have revolutionized …
New perspectives on APC control of cell fate and proliferation in colorectal cancer
RA Phelps, TJ Broadbent, DM Stafforini, DA Jones - Cell cycle, 2009 - Taylor & Francis
Aberrant Wnt/β-catenin signaling following loss of the tumor suppressor adenomatous
polyposis coli (APC) is thought to initiate colon adenoma formation. Considerable evidence …
polyposis coli (APC) is thought to initiate colon adenoma formation. Considerable evidence …
[HTML][HTML] PLA2 (group IIA phospholipase A2) as a prognostic determinant in stage II colorectal carcinoma
Background: Approximately 30% of all colorectal cancer (CRC) patients are diagnosed with
stage II disease. Adjuvant therapy is not widely recommended. However, it is well …
stage II disease. Adjuvant therapy is not widely recommended. However, it is well …
Chemopreventive efficacy of naproxen and nitric oxide–naproxen in rodent models of colon, urinary bladder, and mammary cancers
VE Steele, CV Rao, Y Zhang, J Patlolla, D Boring… - Cancer Prevention …, 2009 - AACR
Nonsteroidal anti-inflammatory drugs (NSAID) have been highly effective in preventing
colon, urinary bladder, and skin cancer preclinically, and also in clinical trials of colon …
colon, urinary bladder, and skin cancer preclinically, and also in clinical trials of colon …
Epidermal Growth Factor Receptor Is Required for Colonic Tumor Promotion by Dietary Fat in the Azoxymethane/Dextran Sulfate Sodium Model: Roles of …
U Dougherty, D Cerasi, I Taylor, M Kocherginsky… - Clinical Cancer …, 2009 - AACR
Purpose: Colon cancer is a major cause of cancer deaths. Dietary factors contribute
substantially to the risk of this malignancy. Western-style diets promote development of …
substantially to the risk of this malignancy. Western-style diets promote development of …
Curcumin potentiates the anti-inflammatory activity of cyclooxygenase inhibitors in the cotton pellet granuloma pouch model.
Curcumin is a yellow-colored plant polyphenol with a long history of medicinal use in
ayurvedic, Chinese and Japanese medicine. Studies have reported the cyclooxygenase …
ayurvedic, Chinese and Japanese medicine. Studies have reported the cyclooxygenase …
Inhibition of cyclooxygenase‐2 suppresses lymph node metastasis via VEGF‐C
H Liu, Y Yang, J Xiao, Y Lv, Y Liu… - … Record: Advances in …, 2009 - Wiley Online Library
Most experimental work addressing cyclooxygenase‐2 (COX‐2) inhibitor has focused on
suppressing hematogenic spread. Little is known about the mechanism by which this …
suppressing hematogenic spread. Little is known about the mechanism by which this …
[HTML][HTML] Reversibility of aberrant global DNA and estrogen receptor-α gene methylation distinguishes colorectal precancer from cancer
R Shen, L Tao, Y Xu, S Chang… - … journal of clinical and …, 2009 - ncbi.nlm.nih.gov
Alterations in the global methylation of DNA and in specific regulatory genes are two
epigenetic alterations found in cancer. However, the significance of epigenetic changes for …
epigenetic alterations found in cancer. However, the significance of epigenetic changes for …
Inhibition of azoxymethane-induced colorectal cancer by CP-31398, a TP53 modulator, alone or in combination with low doses of celecoxib in male F344 rats
CV Rao, VE Steele, MV Swamy, JMR Patlolla… - Cancer research, 2009 - AACR
Tumor suppressor p53 plays a major role in colorectal cancer development. The present
study explores the effects of p53-modulating agent CP-31398 alone and combined with …
study explores the effects of p53-modulating agent CP-31398 alone and combined with …