Genetics of human aggressive behaviour

IW Craig, KE Halton - Human genetics, 2009 - Springer
A consideration of the evolutionary, physiological and anthropological aspects of aggression
suggests that individual differences in such behaviour will have important genetic as well as …

Imaging genetics in ADHD: a focus on cognitive control

S Durston, P de Zeeuw, WG Staal - Neuroscience & Biobehavioral …, 2009 - Elsevier
This paper evaluates neuroimaging of cognitive control as an endophenotype for
investigating the role of dopamine genes in ADHD. First, this paper reviews both data-driven …

Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice

L Gutknecht, C Kriegebaum, J Waider, A Schmitt… - European …, 2009 - Elsevier
Dysregulation of tryptophan hydroxylase (TPH)-dependent serotonin (5-HT) synthesis, has
been implicated in various neuropsychiatric disorders, although the differential expression …

TPH2-703G/T SNP may have important effect on susceptibility to suicidal behavior in major depression

HK Yoon, YK Kim - Progress in Neuro-Psychopharmacology and …, 2009 - Elsevier
BACKGROUND: Serotonergic system-related genes can be good candidate genes for both
major depressive disorder (MDD) and suicidal behavior. In this study, we aimed to …

Tryptophan as an evolutionarily conserved signal to brain serotonin: molecular evidence and psychiatric implications

S Russo, IP Kema, F Bosker, J Haavik… - The world journal of …, 2009 - Taylor & Francis
The role of serotonin (5-HT) in psychopathology has been investigated for decades. Among
others, symptoms of depression, panic, aggression and suicidality have been associated …

Emotionally controlled decisionmaking and a gene variant related to serotonin synthesis in women with borderline personality disorder

L Maurex, G Zaboli, S Wiens, M Åsberg… - Scandinavian …, 2009 - Wiley Online Library
The Iowa Gambling Task (IGT) was used to examine (i) social decisionmaking in women
with borderline personality disorder (BPD), and (ii) the relationship between impaired …

Molecular cloning, characterization and expression of two tryptophan hydroxylase (TPH-1 and TPH-2) genes in the hypothalamus of Atlantic croaker: down-regulation …

MS Rahman, P Thomas - Neuroscience, 2009 - Elsevier
Recently we discovered that hypoxia causes marked impairment of reproductive
neuroendocrine function in Atlantic croaker, a marine teleost, which is due to a decline in …

Genes within the serotonergic system are differentially expressed in human brain

K Sugden, A Tichopad, N Khan, IW Craig… - BMC neuroscience, 2009 - Springer
Background Serotonin is an important neurotransmitter with wide-ranging functions
throughout the central nervous system. There is strong evidence to suggest that regulation of …

Predominant expression of tryptophan hydroxylase 1 mRNA in the pituitary: a postmortem study in human brain

P Zill, A Büttner, W Eisenmenger, J Müller, HJ Möller… - Neuroscience, 2009 - Elsevier
Although the predominant role of tryptophan hydroxylase 2 (TPH2) in the CNS and its
influence on the vulnerability to psychiatric disorders have clearly been demonstrated in …

TPH2 polymorphisms may modify clinical picture in treatment-resistant depression

S Anttila, M Viikki, K Huuhka, M Huuhka, H Huhtala… - Neuroscience …, 2009 - Elsevier
The association of two tryptophan hydroxylase 2 (TPH2) polymorphisms and treatment
response in electroconvulsive therapy (ECT) and the risk of depression was studied. The …