Actinoporins are effective pore-forming toxins produced by sea anemones. These extremely
potent, basic 20kDa proteins readily form pores in membranes that contain sphingomyelin …

Pro-apoptotic Bax is a soluble and monomeric protein under normal physiological
conditions. Upon its activation substantial structural rearrangements occur: The protein …

Bcl-2 family proteins regulate apoptosis through their homo-and heterodimerization. By
protein sequence analysis and structural comparison, we have identified a conserved …

This thesis reports the studies of the structure and mechanism of peptide-induced
membrane pores by antimicrobial peptide alamethicin and by a peptide named Baxα5 …

Figure 1: Schematic representation of innate immune sensors or pattern recognition
receptors (PRR). TLR are classical transmembrane proteins composed of variable number …

Apoptosis is a highly orderly process, which is important for development, maintaining tissue
normality as well as the prevention of diseases. The mechanism of apoptosis is very …