Presents the State-of-the-Art in Fat Taste TransductionA bite of cheese, a few potato chips, a
delectable piece of bacon-a small taste of high-fat foods often draws you back for more. But …

Obesity is a major health problem in industrialized societies often associated with diabetes,
insulin resistance, and hepatic steatosis. This review addresses the hypothesis that …

Elongation of very long chain fatty acids (ELOVL) 5 is one of seven mammalian fatty acid
condensing enzymes involved in microsomal fatty acid elongation. To determine the in vivo …

Very long chain fatty acids confer functional diversity on cells by variations in their chain
length and degree of unsaturation. Microsomal fatty acid elongation represents the major …

Diets high in fructose cause hypertriglyceridemia and insulin resistance in part due to
simultaneous induction of gluconeogenic and lipogenic genes in liver. We investigated the …

The nuclear receptor constitutive androstane receptor (CAR)(NR1I3) regulates hepatic
genes involved in xenobiotic detoxification as well as genes involved in energy …

Autism is a neurological disorder that manifests as noticeable behavioral and
developmental abnormalities predominantly in males between the ages of 2 and 10 …

Regulation between the fed and fasted states in mammals is partially controlled by
peroxisome proliferator‐activated receptor‐α (PPAR‐α). Expression of the receptor is high in …

Leptin reduces body weight in ob/ob mice by decreasing food intake and increasing energy
expenditure; however, the mechanisms by which it does the latter are not known. Here we …

We established a convenient assay method for measuring elongation of very long chain fatty
acids (ELOVLs) using a Unifilter-96 GF/C plate. The Unifilter GF/C plate preferentially …