Menopause is associated with a natural decline in estrogen, that increases visceral fat mass,
decreases bone mass density, muscle mass, and strength. This review will examine the role …

Lipotoxicity in skeletal muscle plays a critical role in the aetiology of insulin resistance and
type 2 diabetes mellitus by interference of lipid metabolites with insulin signalling and action …

OBJECTIVE Age-associated insulin resistance may underlie the higher prevalence of type 2
diabetes in older adults. We examined a corollary hypothesis that obesity and level of …

This brief review focuses on the genetic contribution to childhood obesity. Evidence for a
genetic component to excess body weight during growth is presented from the perspective …

The prevalence of obesity appears to have reached a plateau in the US between 2003 and
2007 (1), but the obesity epidemic is still rampant in many other countries—especially in the …

Data from the health survey for England 2006 1, showed that the prevalence of type 2
diabetes mellitus (T2DM) has more than doubled in men and women since 1991. In the USA …

Context: Obesity-related insulin resistance of glucose and lipid metabolism may also affect
protein kinetics, notably at the muscle level. Objective: We hypothesized that muscle protein …

Obesity represents a disruption in balancing fuel intake with energy expenditure in favor of
energy conservation. Adiposity is known to be carefully regulated and, over time, highly …

A reduction in fatty acid (FA) oxidation has been associated with lipid accumulation and
insulin resistance in skeletal muscle of obese individuals. Numerous reports suggest that the …

We hypothesized that plasma non‐esterified fatty acids (NEFA) are trafficked directly to
intramyocellular long‐chain acylcarnitines (imLCAC) rather than transiting intramyocellular …