α-Synuclein is an abundant highly charged protein that is normally predominantly localized
around synaptic vesicles in presynaptic terminals. Although the function of this protein is still …

α‐Synuclein is an intrinsically unfolded protein that can adopt a partially helical structure
when it interacts with different lipid membranes. Its pathological relevance is linked to its …

A hallmark of polyglutamine diseases, including Huntington disease (HD), is the formation of
β-sheet-rich aggregates, called amyloid, of causative proteins with expanded …

Microglia provide immune surveillance for the brain through both the removal of cellular
debris and protection against infection by microorganisms and “foreign” molecules. Upon …

The extracellular curli proteins of Enterobacteriaceae form fibrous structures that are
involved in biofilm formation and adhesion to host cells. These curli fibrils are considered a …

The molecular mechanism underlying the flavonoid-induced inhibition of α-synuclein
fibrillation was thoroughly examined by various biochemical and biophysical approaches …

During the last decades, considerable advances in the understanding of specific
mechanisms underlying neurodegeneration in Parkinson's disease have been achieved, yet …

Fibrillization or conformational change of α-synuclein is central in the pathogenesis of α-
synucleinopathies, such as Parkinson disease. We found that the A30P mutant accelerates …

The evidence for impairment in the ubiquitin proteasome system (UPS) in Parkinson's
disease (PD) is mounting and becoming increasingly more convincing. However, it is …

The role of α-synuclein in pathogenesis of familial and idiopathic forms of Parkinson's
disease, and other human disorders known as α-synucleinopathies, is well established. In …