JAK redux: a second look at the regulation and role of JAKs in the heart
M Kurdi, GW Booz - American Journal of Physiology-Heart …, 2009 - journals.physiology.org
A number of type 1 receptor cytokine family members protect the heart from acute and
chronic oxidative stress. This protection involves activation of two intracellular signaling …
chronic oxidative stress. This protection involves activation of two intracellular signaling …
Chronic infusion of angiotensin-(1–7) improves insulin resistance and hypertension induced by a high-fructose diet in rats
JF Giani, MA Mayer, MC Munoz… - American Journal …, 2009 - journals.physiology.org
The current study was undertaken to determine whether Ang-(1–7) is effective in improving
metabolic parameters in fructose-fed rats (FFR), a model of metabolic syndrome. Six-week …
metabolic parameters in fructose-fed rats (FFR), a model of metabolic syndrome. Six-week …
Angiotensin-(1–7) activates growth-stimulatory pathways in human mesangial cells
J Zimpelmann, KD Burns - American Journal of Physiology …, 2009 - journals.physiology.org
Angiotensin-(1–7)[Ang-(1–7)] is generated in part via ACE2-dependent degradation of
angiotensin II (ANG II). In proximal tubular cells, Ang-(1–7) inhibits ANG II-stimulated …
angiotensin II (ANG II). In proximal tubular cells, Ang-(1–7) inhibits ANG II-stimulated …
Angiotensin-(1–7) activates a tyrosine phosphatase and inhibits glucose-induced signalling in proximal tubular cells
E Gava, A Samad-Zadeh, J Zimpelmann… - Nephrology Dialysis …, 2009 - academic.oup.com
Background. In the diabetic kidney, stimulation of mitogen-activated protein kinases
(MAPKs) leads to extracellular matrix protein synthesis. In the proximal tubule, angiotensin …
(MAPKs) leads to extracellular matrix protein synthesis. In the proximal tubule, angiotensin …
Therapeutic perspectives of angiotensin-(1-7) in the treatment of cardiovascular disease
C Höcht, M Mayer, CA Taira - The Open Pharmacology Journal, 2009 - benthamopen.com
In the last decade, new biologically active components of the renin-angiotensin system were
found. Angiotensin-(1-7)(Ang-(1-7)), a metabolite of angiotensin I and angiotensin II (Ang II) …
found. Angiotensin-(1-7)(Ang-(1-7)), a metabolite of angiotensin I and angiotensin II (Ang II) …