Genetic diversity and malaria vaccine design, testing and efficacy: preventing and overcoming 'vaccine resistant malaria'
SL Takala, CV Plowe - Parasite immunology, 2009 - Wiley Online Library
The development of effective malaria vaccines may be hindered by extensive genetic
diversity in the surface proteins being employed as vaccine antigens. Understanding of the …
diversity in the surface proteins being employed as vaccine antigens. Understanding of the …
Rapidly evolving genes in pathogens: methods for detecting positive selection and examples among fungi, bacteria, viruses and protists
The ongoing coevolutionary struggle between hosts and pathogens, with hosts evolving to
escape pathogen infection and pathogens evolving to escape host defences, can generate …
escape pathogen infection and pathogens evolving to escape host defences, can generate …
Analysis of immunity to febrile malaria in children that distinguishes immunity from lack of exposure
In studies of immunity to malaria, the absence of febrile malaria is commonly considered
evidence of “protection.” However, apparent “protection” may be due to a lack of exposure to …
evidence of “protection.” However, apparent “protection” may be due to a lack of exposure to …
Molecular approaches to diversity of populations of apicomplexan parasites
HP Beck, D Blake, ML Dardé, I Felger… - International journal for …, 2009 - Elsevier
Apicomplexan parasites include many parasites of importance either for livestock or as
causative agents of human diseases. The importance of these parasites has been …
causative agents of human diseases. The importance of these parasites has been …
Prospective identification of malaria parasite genes under balancing selection
Background Endemic human pathogens are subject to strong immune selection, and
interrogation of pathogen genome variation for signatures of balancing selection can identify …
interrogation of pathogen genome variation for signatures of balancing selection can identify …
Functional Memory B Cells and Long-Lived Plasma Cells Are Generated after a Single Plasmodium chabaudi Infection in Mice
FM Ndungu, ET Cadman, J Coulcher, E Nduati… - PLoS …, 2009 - journals.plos.org
Antibodies have long been shown to play a critical role in naturally acquired immunity to
malaria, but it has been suggested that Plasmodium-specific antibodies in humans may not …
malaria, but it has been suggested that Plasmodium-specific antibodies in humans may not …
Genetic diversity in Plasmodium falciparum merozoite surface protein 1 and 2 coding genes and its implications in malaria epidemiology: a review of published …
GN Kiwanuka - 2009 - nru.uncst.go.ug
A major characteristic of human malaria parasites is their genetic diversity and an increasing
number of studies have been reported on the epidemiology of Plasmodium falciparum …
number of studies have been reported on the epidemiology of Plasmodium falciparum …
Anti–MSP1 block 2 antibodies are effective at parasite killing in an allele-specific manner by monocyte-mediated antibody-dependent cellular inhibition
CD Galamo, A Jafarshad, C Blanc… - The Journal of …, 2009 - academic.oup.com
We investigated whether anti–merozoite surface protein-1 (MSP1) block 2 antibodies
mediate the monocyte-dependent antibody-mediated cellular inhibition (ADCI) of …
mediate the monocyte-dependent antibody-mediated cellular inhibition (ADCI) of …
[HTML][HTML] Plasmodium falciparum and Plasmodium vivax infections in the Peruvian Amazon: propagation of complex, multiple allele-type infections without super …
PL Sutton, V Neyra, JN Hernandez… - The American journal of …, 2009 - ncbi.nlm.nih.gov
Outcrossing potential between Plasmodium parasites is defined by the population-level
diversity (PLD) and complexity of infection (COI). There have been few studies of PLD and …
diversity (PLD) and complexity of infection (COI). There have been few studies of PLD and …
Population diversity and antibody selective pressure to Plasmodium falciparum MSP1 block2 locus in an African malaria-endemic setting
N Noranate, F Prugnolle, H Jouin, A Tall, L Marrama… - BMC microbiology, 2009 - Springer
Background Genetic evidence for diversifying selection identified the Merozoite Surface
Protein1 block2 (PfMSP1 block2) as a putative target of protective immunity against …
Protein1 block2 (PfMSP1 block2) as a putative target of protective immunity against …