Folate-targeted therapeutic and imaging agents for cancer

PS Low, SA Kularatne - Current opinion in chemical biology, 2009 - Elsevier
Cancer therapies that exploit targeting ligands to deliver attached cytotoxic drugs selectively
to malignant cells are currently receiving significant attention. While antibody-targeted drugs …

Multifunctional and stimuli-sensitive pharmaceutical nanocarriers

V Torchilin - European Journal of Pharmaceutics and …, 2009 - Elsevier
Currently used pharmaceutical nanocarriers, such as liposomes, micelles, and polymeric
nanoparticles, demonstrate a broad variety of useful properties, such as longevity in the …

Gold Nanorods as Contrast Agents for Biological Imaging: Optical Properties, Surface Conjugation and Photothermal Effects

L Tong, Q Wei, A Wei, JX Cheng - Photochemistry and …, 2009 - Wiley Online Library
Gold nanorods (NRs) have plasmon‐resonant absorption and scattering in the near‐infrared
(NIR) region, making them attractive probes for in vitro and in vivo imaging. In the cellular …

Dendrimers in oncology: an expanding horizon

RK Tekade, PV Kumar, NK Jain - Chemical reviews, 2009 - ACS Publications
Cancer is a killer disease second only to heart problems. 1 Though there is significant
progress in the field of anticancer technology, we are still badly in need of a reliable cure for …

Targeting and imaging cancer cells by folate-decorated, quantum dots (QDs)-loaded nanoparticles of biodegradable polymers

J Pan, SS Feng - Biomaterials, 2009 - Elsevier
We developed a new strategy to prepare folate-decorated nanoparticles of biodegradable
polymers for Quantum dots (QDs) formulation for targeted and sustained imaging for cancer …

Dendrimer-based nanoparticles for cancer therapy

JR Baker Jr - ASH Education Program Book, 2009 - ashpublications.org
Recent work has suggested that nanoparticles in the form of dendrimers may be a keystone
in the future of therapeutics. The field of oncology could soon be revolutionized by novel …

Dendrimers and nanomedicine: multivalency in action

O Rolland, CO Turrin, AM Caminade… - New Journal of …, 2009 - pubs.rsc.org
What is the contribution of dendrimers to the field of nanomedicine? Rather than disclosing
an exhaustive catalogue of their possible applications, this review article sets a putative …

Bio-conjugated luminescent quantum dots of doped ZnS: a cyto-friendly system for targeted cancer imaging

K Manzoor, S Johny, D Thomas, S Setua… - …, 2009 - iopscience.iop.org
A heavy-metal-free luminescent quantum dot (QD) based on doped zinc sulfide (ZnS),
conjugated with a cancer-targeting ligand, folic acid (FA), is presented as a promising bio …

Oligomeric compounds for the modulation of Bcl-2

M Frieden, JB Hansen, H Orum, M Westergaard… - US Patent …, 2009 - Google Patents
The present invention provides improved oligomeric com pound, in particular
oligonucleotide compounds, and meth ods for modulating the expression of the Bcl-2 gene …

Biotinylated poly (amido) amine (PAMAM) dendrimers as carriers for drug delivery to ovarian cancer cells in vitro

VK Yellepeddi, A Kumar, S Palakurthi - Anticancer research, 2009 - ar.iiarjournals.org
Background: Biotin is an essential micronutrient and its levels are high in rapidly
proliferating cells such as cancer cells. We hypothesized that the synthesis of poly (amido) …