The failure of mitochondria leads to neurodegeneration: Do mitochondria need a jump start?
Mitochondria are the power engine generating biochemical energy in the cell. Mitochondrial
dysfunction and bioenergy deficiency is closely linked to the pathogenesis of …
dysfunction and bioenergy deficiency is closely linked to the pathogenesis of …
Alpha-lipoic acid attenuates cisplatin-induced acute kidney injury in mice by suppressing renal inflammation
KP Kang, DH Kim, YJ Jung, AS Lee… - Nephrology Dialysis …, 2009 - academic.oup.com
Background. Cisplatin is a chemotherapeutic agent used in treatment of malignant tumours.
However, cisplatin produces various side effects, such as nephrotoxicity, neurotoxicity …
However, cisplatin produces various side effects, such as nephrotoxicity, neurotoxicity …
Oxidative stress in the hippocampus during experimental seizures can be ameliorated with the antioxidant ascorbic acid
ÍMS Santos, AR Tomé, GB Saldanha… - Oxidative medicine …, 2009 - Wiley Online Library
Ascorbic acid has many nonenzymatic actions and is a powerful water‐soluble antioxidant. It
protects low density lipoproteins from oxidation and reduces harmful oxidants in the central …
protects low density lipoproteins from oxidation and reduces harmful oxidants in the central …
The evaluation of effects of lipoic acid on the lipid peroxidation, nitrite formation and antioxidant enzymes in the hippocampus of rats after pilocarpine-induced seizures
RM Freitas - Neuroscience letters, 2009 - Elsevier
It has been suggested that pilocarpine-induced seizures is mediated by increases in
oxidative stress. Current researches have suggested that antioxidant compounds may afford …
oxidative stress. Current researches have suggested that antioxidant compounds may afford …
Preventive effects of Chlorella on cognitive decline in age-dependent dementia model mice
Y Nakashima, I Ohsawa, F Konishi, T Hasegawa… - Neuroscience …, 2009 - Elsevier
Oxidative stress is one of the major causes of age-dependent memory loss and cognitive
decline. Cytotoxic aldehydes are derived from lipid peroxides and their accumulation may …
decline. Cytotoxic aldehydes are derived from lipid peroxides and their accumulation may …
[HTML][HTML] Yersiniabactin reduces the respiratory oxidative stress response of innate immune cells
A Paauw, MA Leverstein-van Hall, KPM van Kessel… - PLoS one, 2009 - journals.plos.org
Enterobacteriaceae that contain the High Pathogenicity Island (HPI), which encodes the
siderophore yersiniabactin, display increased virulence. This increased virulence may be …
siderophore yersiniabactin, display increased virulence. This increased virulence may be …
Distribution study of orally administered lipoic acid in rat brain tissues
HT Chng, LS New, AH Neo, CW Goh, ER Browne… - Brain research, 2009 - Elsevier
Lipoic acid (LA), an essential cofactor for mitochondrial enzymes and a natural antioxidant,
has been explored for the treatment of Alzheimer's disease. However, lipoic acid distribution …
has been explored for the treatment of Alzheimer's disease. However, lipoic acid distribution …
Multifunctional lipoic acid conjugates
Several hundreds of studies published the last decade have reported that α-lipoic acid (LA)
possesses the potential to intervene in various therapeutically interesting pathways …
possesses the potential to intervene in various therapeutically interesting pathways …
Lactic acid in cancer and mitochondrial disease
K Steliou, SP Perrine, DV Faller - Drug Development Research, 2009 - Wiley Online Library
Cancer and the mitochondrial diseases are disparate disorders that have in common a
failure of normal cellular respiratory activity in disease‐affected tissues. In mitochondrial …
failure of normal cellular respiratory activity in disease‐affected tissues. In mitochondrial …