Many gene defects are relatively easy to identify experimentally, but obtaining information
about the effects of sequence variations and elucidation of the detailed molecular …

Aggregation of a biotherapeutic is of significant concern and judicious process and
formulation development is required to minimize aggregate levels in the final product …

Alzheimer s disease (AD), a neurodegenerative disorder for which there is no disease-
modifying therapy, is the foremost cause of dementia in elderly people.[1] An initial …

Peptide self-assembly processes are central to the etiology of amyloid diseases. Much effort
has been devoted to characterizing amyloid structure and the mechanisms of peptideself …

There has been great interest recently in peptide amphiphiles and block copolymers
containing biomimetic peptide sequences due to applications in bionanotechnology. We …

The human islet amyloid polypeptide (hIAPP) or amylin is a 37-residue hormone found as
amyloid deposits in pancreatic extracts of nearly all type 2 diabetes patients. The fragment …

The potential of human glucagon-like peptide-1 (hGLP-1) as a therapeutic agent is limited
by its high aggregation propensity. We show that hGLP-1 forms amyloid-like structures that …

The principal component of the amyloid deposits in Alzheimer's disease is the β-amyloid
polypeptide, while in type II diabetes the deposits consist primarily of Islet amyloid …

The direct synthesis of a ketomethylene isostere of the fibril-forming decapeptide
SNNFGAILSS is presented with the goal of understanding how small structural changes …

Time-resolved/steady-state fluorescence and mass spectrometry measurements have
shown the preferential binding of a non-steroidal anti-inflammatory drug (NSAID) like …