Chromatin immunoprecipitation followed by sequencing (ChIP–seq) is a technique for
genome-wide profiling of DNA-binding proteins, histone modifications or nucleosomes …

The packaging of chromosomal DNA by nucleosomes condenses and organizes the
genome, but occludes many regulatory DNA elements. However, this constraint also allows …

Knowing the precise locations of nucleosomes in a genome is key to understanding how
genes are regulated. Recent'next generation'ChIP–chip and ChIP–Seq technologies have …

Nucleosome organization is critical for gene regulation. In living cells this organization is
determined by multiple factors, including the action of chromatin remodellers, competition …

Genome-wide pervasive transcription has been reported in many eukaryotic organisms,,,,,,,
revealing a highly interleaved transcriptome organization that involves hundreds of …

To understand how chromatin structure is organized by different histone variants, we have
measured the genome-wide distribution of nucleosome core particles (NCPs) containing the …

Chromatin is a highly regulated nucleoprotein complex through which genetic material is
structured and maneuvered to elicit cellular processes, including transcription, cell division …

We describe a broad mechanistic framework for the transcriptional induction of mammalian
primary response genes by Toll-like receptors and other stimuli. One major class of primary …

The orchestrated binding of transcriptional activators and repressors to specific DNA
sequences in the context of chromatin defines the regulatory program of eukaryotic …

The regulation of gene transcription involves a dynamic balance between packaging
regulatory sequences into chromatin and allowing transcriptional regulators access to these …