The FGF family: biology, pathophysiology and therapy
A Beenken, M Mohammadi - Nature reviews Drug discovery, 2009 - nature.com
The family of fibroblast growth factors (FGFs) regulates a plethora of developmental
processes, including brain patterning, branching morphogenesis and limb development …
processes, including brain patterning, branching morphogenesis and limb development …
Bone as an endocrine organ
S Fukumoto, TJ Martin - Trends in Endocrinology & Metabolism, 2009 - cell.com
Although bone has long been recognized as a target for hormones influencing calcium and
phosphorus homeostasis and bone structure, recent evidence shows that the skeleton itself …
phosphorus homeostasis and bone structure, recent evidence shows that the skeleton itself …
Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
J Xu, DJ Lloyd, C Hale, S Stanislaus, M Chen… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE—Fibroblast growth factor 21 (FGF21) has emerged as an important metabolic
regulator of glucose and lipid metabolism. The aims of the current study are to evaluate the …
regulator of glucose and lipid metabolism. The aims of the current study are to evaluate the …
FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
The liver plays a crucial role in mobilizing energy during nutritional deprivation. During the
early stages of fasting, hepatic glycogenolysis is a primary energy source. As fasting …
early stages of fasting, hepatic glycogenolysis is a primary energy source. As fasting …
FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1
J Gattineni, C Bates, K Twombley… - American Journal …, 2009 - journals.physiology.org
Fibroblast growth factor-23 (FGF23) is a phosphaturic hormone that contributes to several
hypophosphatemic disorders by reducing the expression of the type II sodium-phosphate …
hypophosphatemic disorders by reducing the expression of the type II sodium-phosphate …
Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance
AO Chavez, M Molina-Carrion, MA Abdul-Ghani… - Diabetes …, 2009 - Am Diabetes Assoc
OBJECTIVE Fibroblast growth factor (FGF)-21 is highly expressed in the liver and regulates
hepatic glucose production and lipid metabolism in rodents. However, its role in the …
hepatic glucose production and lipid metabolism in rodents. However, its role in the …
Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects
J Xu, S Stanislaus, N Chinookoswong… - American Journal …, 2009 - journals.physiology.org
Recombinant fibroblast growth factor (FGF) 21 has antihyperglycemic, antihyperlipidemic,
and antiobesity effects in diabetic rodent and monkey models. Previous studies were …
and antiobesity effects in diabetic rodent and monkey models. Previous studies were …
[HTML][HTML] In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23)-mediated regulation of systemic phosphate homeostasis
T Nakatani, B Sarraj, M Ohnishi, MJ Densmore… - The FASEB …, 2009 - ncbi.nlm.nih.gov
A major breakthrough in systemic phosphate homeostasis regulation was achieved by the
demonstration of strikingly similar physical, morphological, and biochemical phenotypes of …
demonstration of strikingly similar physical, morphological, and biochemical phenotypes of …
Initial FGF23-mediated signaling occurs in the distal convoluted tubule
EG Farrow, SI Davis, LJ Summers… - Journal of the American …, 2009 - journals.lww.com
Abstract Fibroblast growth factor-23 (FGF23), a hormone central to phosphate and vitamin D
metabolism, reduces renal absorption of phosphate by downregulating the sodium …
metabolism, reduces renal absorption of phosphate by downregulating the sodium …
Differential interactions of FGFs with heparan sulfate control gradient formation and branching morphogenesis
HP Makarenkova, MP Hoffman, A Beenken… - Science …, 2009 - science.org
The developmental activities of morphogens depend on the gradients that they form in the
extracellular matrix. Here, we show that differences in the binding of fibroblast growth factor …
extracellular matrix. Here, we show that differences in the binding of fibroblast growth factor …