Approximately 5% to 10% of melanoma may be hereditary in nature, and about 2% of
melanoma can be specifically attributed to pathogenic germline mutations in cyclin …

Melanoma is a complex, heterogeneous cancer that continues to increase in incidence.
Multiple studies have consistently identified major host and environmental risk factors for …

Purpose: The aim of this prospective cohort study was to examine uptake and psychological,
behavioral, and cognitive outcomes of genetic testing for melanoma risk among individuals …

As the incidence of malignant melanoma continues to increase and with the completion of
the sequencing of the human genome, there have been increasing efforts to identify the …

Dysplastic nevi have become an increasing focus clinically, with evidence that they are
associated with a higher risk of developing melanoma. However, there still is contention …

Germline mutations of the CDKN2A gene are found in melanoma‐prone families and
individuals with multiple sporadic melanomas. The encoded protein, p16INK4A, comprises …

The notion that melanoma has a genetic component was posited by William Norris in some
of the earliest descriptions of the disease. 1 The general practitioner noted that some cases …

The clinical manifestations of hereditary skin cancer syndromes depend upon the interplay
between environmental and genetic factors. Familial melanoma occurs in the setting of …

The incidence of cutaneous malignant melanoma has increased in young adults, specifically
in Denmark. In this study, we examined the risk of cutaneous malignant melanoma in …

Despite many studies on pathology and aetiology during the past decades, the molecular
mechanism (s) of melanoma development remains largely unknown. Therefore the purpose …