Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065
KS MacMillan, DL Boger - Journal of medicinal chemistry, 2009 - ACS Publications
The duocarmycins (1 and 2) 1 belong to a small family of natural products (Figure 1) that
also include yatakemycin (3) 2 and CC-1065 (4). 3 Their exceptionally potent cytotoxic …
also include yatakemycin (3) 2 and CC-1065 (4). 3 Their exceptionally potent cytotoxic …
Studies toward the duocarmycin prodrugs for the antibody prodrug therapy approach
LS Li, SC Sinha - Tetrahedron letters, 2009 - Elsevier
A tricyclic precursor for the synthesis of the prodrugs of pro-1, 2, 9, 9a-tetrahydrocyclopropa
[c] benz-[e] indole-4-one tetramethoxyindolecarboxamide (CBI-TMI) was prepared using the …
[c] benz-[e] indole-4-one tetramethoxyindolecarboxamide (CBI-TMI) was prepared using the …
Synthesis and preliminary evaluation of duocarmycin analogues incorporating the 1, 2, 11, 11a-tetrahydrocyclopropa [c] naphtho [2, 3-e] indol-4-one (CNI) and 1, 2, 11 …
CM Gauss, A Hamasaki, JP Parrish, KS MacMillan… - Tetrahedron, 2009 - Elsevier
Efficient syntheses and a preliminary evaluation of 1, 2, 11, 11a-tetrahydrocyclopropa [c]
naphtho [2, 3-e]-indole (CNI) and 1, 2, 11, 11a-tetrahydrocyclopropa [c] naphtho [1, 2-e] …
naphtho [2, 3-e]-indole (CNI) and 1, 2, 11, 11a-tetrahydrocyclopropa [c] naphtho [1, 2-e] …