Abstract Interleukin-17A (IL-17A), the hallmark cytokine of the newly defined T helper 17
(TH17) cell subset, has important roles in protecting the host against extracellular …

Numerous short-lived and highly reactive oxygen species (ROS) such as superoxide (O2−),
hydroxyl radical, and hydrogen peroxide are continuously generated in vivo. Depending …

Transcription is a molecular requisite for long-term synaptic plasticity and long-term memory
formation. Thus, in the last several years, one main interest of molecular neuroscience has …

Growth cone guidance and synaptic plasticity involve dynamic local changes in proteins at
axons and dendrites. The Dual-Leucine zipper Kinase MAPKKK (DLK) has been previously …

Synaptic activity can boost neuroprotection through a mechanism that requires synapse-to-
nucleus communication and calcium signals in the cell nucleus. Here we show that in …

Low‐grade inflammation, a minor elevation in the baseline concentration of inflammatory
markers such as C‐reactive protein (CRP), is nowadays recognized as an important …

Background Adipose tissues serve not only as a store for energy in the form of lipid, but also
as endocrine tissues that regulates metabolic activities of the organism by secreting various …

Macrophages (Mφ) are prominent components of solid tumors and exhibit distinct
phenotypes in different microenvironments. We have recently found that tumors can alter the …

The CCAAT/enhancer-binding proteins (C/EBPs) are a family of leucine-zipper transcription
factors that regulate gene expression to control cellular proliferation, differentiation …

Differentiation is a complex set of events that can be blocked by rearrangements of
regulatory genes producing fusion proteins with altered properties. In the case of myxoid …