Single-molecule studies of the neuronal SNARE fusion machinery
AT Brunger, K Weninger, M Bowen… - Annual review of …, 2009 - annualreviews.org
SNAREs are essential components of the machinery for Ca2+-triggered fusion of synaptic
vesicles with the plasma membrane, resulting in neurotransmitter release into the synaptic …
vesicles with the plasma membrane, resulting in neurotransmitter release into the synaptic …
Calcium influx and signaling in cytotoxic T‐lymphocyte lytic granule exocytosis
AT Pores‐Fernando, A Zweifach - Immunological reviews, 2009 - Wiley Online Library
Cytotoxic T lymphocytes (CTLs) kill targets by releasing cytotoxic agents from lytic granules.
Killing is a multi‐step process. The CTL adheres to a target, allowing its T‐cell receptors to …
Killing is a multi‐step process. The CTL adheres to a target, allowing its T‐cell receptors to …
[HTML][HTML] ELKS2α/CAST deletion selectively increases neurotransmitter release at inhibitory synapses
The presynaptic active zone is composed of a protein network that contains ELKS2α (aka
CAST) as a central component. Here we demonstrate that in mice, deletion of ELKS2α …
CAST) as a central component. Here we demonstrate that in mice, deletion of ELKS2α …
A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1
X Wang, B Hu, A Zieba, NG Neumann… - Journal of …, 2009 - Soc Neuroscience
Multidomain scaffolding proteins organize the molecular machinery of neurotransmitter
vesicle dynamics during synaptogenesis and synaptic activity. We find that domains of five …
vesicle dynamics during synaptogenesis and synaptic activity. We find that domains of five …
Presynaptic signal transduction pathways that modulate synaptic transmission
APH de Jong, M Verhage - Current opinion in neurobiology, 2009 - Elsevier
Presynaptic modulation is a crucial factor in the adaptive capacity of the nervous system.
The coupling between incoming action potentials and neurotransmitter secretion is …
The coupling between incoming action potentials and neurotransmitter secretion is …
Structural insights into the calmodulin− munc13 interaction obtained by cross-linking and mass spectrometry
K Dimova, S Kalkhof, I Pottratz, C Ihling… - Biochemistry, 2009 - ACS Publications
Munc13 proteins are essential regulators of synaptic vesicle priming and play a key role in
adaptive synaptic plasticity phenomena. We recently identified and characterized the Ca2+ …
adaptive synaptic plasticity phenomena. We recently identified and characterized the Ca2+ …
The mechanisms of multi-component paired-pulse facilitation of neurotransmitter release at the frog neuromuscular junction
MA Mukhamedyarov, SN Grishin, AL Zefirov… - … -European Journal of …, 2009 - Springer
We have studied the mechanisms of paired-pulse facilitation (PPF) of neurotransmitter
release in isolated nerve-muscle preparations of the frog cutaneous pectoris muscle. In …
release in isolated nerve-muscle preparations of the frog cutaneous pectoris muscle. In …
[PDF][PDF] Gleichzeitige Beobachtung der Exozytose in Chromaffinzellen mit einer Kombination von Interner Totalreflektions-Fluoreszenz-Mikroskopie und …
M Pasche - 2009 - publikationen.sulb.uni-saarland.de
Mit Hilfe der so genannten „Caging Diameter “-Analyse konnte ich zeigen, dass LDCVs bei
einer [Ca2+] i von 600-800 nM maximal lateral immobilisiert wurden. Mit dieser …
einer [Ca2+] i von 600-800 nM maximal lateral immobilisiert wurden. Mit dieser …
Function of the exocsyt complex in the calyx of Held presynaptic nerve terminal
D Schwenger - 2009 - archiv.ub.uni-heidelberg.de
Synaptic vesicles have to be constantly transported to the active zone to ensure ongoing
synaptic transmission. Although some proteins which mediate docking and priming of …
synaptic transmission. Although some proteins which mediate docking and priming of …
Investigation of Rab34 and Munc13 In The Secretory Pathway: Potential Roles In Diabetic Nephropathy
NM Goldenberg - 2009 - library-archives.canada.ca
Constitutive secretion is responsible for the targeting of transmembrane proteins to the
plasma membrane, and for the secretion of extracellular matrix proteins, hormones, and …
plasma membrane, and for the secretion of extracellular matrix proteins, hormones, and …