SNAREs are essential components of the machinery for Ca2+-triggered fusion of synaptic
vesicles with the plasma membrane, resulting in neurotransmitter release into the synaptic …

Cytotoxic T lymphocytes (CTLs) kill targets by releasing cytotoxic agents from lytic granules.
Killing is a multi‐step process. The CTL adheres to a target, allowing its T‐cell receptors to …

The presynaptic active zone is composed of a protein network that contains ELKS2α (aka
CAST) as a central component. Here we demonstrate that in mice, deletion of ELKS2α …

Multidomain scaffolding proteins organize the molecular machinery of neurotransmitter
vesicle dynamics during synaptogenesis and synaptic activity. We find that domains of five …

Presynaptic modulation is a crucial factor in the adaptive capacity of the nervous system.
The coupling between incoming action potentials and neurotransmitter secretion is …

Munc13 proteins are essential regulators of synaptic vesicle priming and play a key role in
adaptive synaptic plasticity phenomena. We recently identified and characterized the Ca2+ …

We have studied the mechanisms of paired-pulse facilitation (PPF) of neurotransmitter
release in isolated nerve-muscle preparations of the frog cutaneous pectoris muscle. In …

Mit Hilfe der so genannten „Caging Diameter “-Analyse konnte ich zeigen, dass LDCVs bei
einer [Ca2+] i von 600-800 nM maximal lateral immobilisiert wurden. Mit dieser …

Synaptic vesicles have to be constantly transported to the active zone to ensure ongoing
synaptic transmission. Although some proteins which mediate docking and priming of …

Constitutive secretion is responsible for the targeting of transmembrane proteins to the
plasma membrane, and for the secretion of extracellular matrix proteins, hormones, and …