The majority of the genome in animals and plants is transcribed in a developmentally
regulated manner to produce large numbers of non–protein-coding RNAs (ncRNAs), whose …

The involvement of SOX9 in congenital skeletal malformation was demonstrated 15 years
ago with the identification of mutations in and around the gene in patients with campomelic …

Background Vertebrates share the same general body plan and organs, possess related
sets of genes, and rely on similar physiological mechanisms, yet show great diversity in …

The three-dimensional molecular structure of DNA, specifically the shape of the backbone
and grooves of genomic DNA, can be dramatically affected by nucleotide changes, which …

Genome-wide analyses of the eukaryotic transcriptome have revealed that the majority of
the genome is transcribed, producing large numbers of non-protein-coding RNAs (ncRNAs) …

Tissue organization in epithelial organs is achieved during development by the combined
processes of cell differentiation and morphogenetic cell movements. In the kidney, the …

Proper development and functioning of an organism depends on precise spatial and
temporal expression of all its genes. These coordinated expression-patterns are maintained …

Evolutionary changes in gene expression are a main driver of phenotypic evolution. In yeast,
genes that have rapidly diverged in expression are associated with particular promoter …

Since the birth of molecular biology it has been generally assumed that most genetic
information is transacted by proteins, and that RNA plays an intermediary role. This led to …

The Wilms' tumor suppressor gene Wt1 encodes a zinc-finger transcription factor that plays
an essential role in organ development, most notably of the kidney. Despite its importance …