Methods to label neurons and to monitor their activity with genetically encoded fluorescent
reporters have been a staple of neuroscience research for several years. The recent …

Combinatorial genetics for conditional transgene activation allows studying gene function
with temporal and tissue specific control like the Gal4-UAS system, which has enabled …

Over recent years, several groundbreaking techniques have been developed that allow for
the anatomical description of neurons, and the observation and manipulation of their activity …

Epigenetic regulation of transcriptional silencing is essential for normal development.
Despite its importance, in vivo systems for examining gene silencing at cellular resolution …

We have carried out a Gal4 enhancer trap screen in zebrafish, and have generated 184
stable transgenic lines with interesting expression patterns throughout the nervous system …

The Gal4-UAS system provides powerful tools to analyze the function of genes and cells in
vivo and has been extensively employed in Drosophila. The usefulness of this approach …

Background Tol2, a member of the hAT family of transposons, has become a useful tool for
genetic manipulation of model animals, but information about its interactions with vertebrate …

Introduction of foreign DNA into the mouse germ line is considered a major technical
advancement in the fields of developmental biology and genetics. This technology now …

Long distance migration of differentiating granule cells from the cerebellar upper rhombic lip
has been reported in many vertebrates. However, the knowledge about the subcellular …

We have established a model of melanoma progression in zebrafish through the generation
of transgenic lines specifically expressing oncogenic human HRAS in the melanocytic …