The dipeptide carnosine has been observed to exert antiaging activity at cellular and whole
animal levels. This review discusses the possible mechanisms by which carnosine may …

Modulation of endogenous cellular defense mechanisms via the stress response signaling
represents an innovative approach to therapeutic intervention in diseases causing chronic …

Hydrogen sulfide (H2S) is an essential physiological product in brain. We investigated the
expression of cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CGL), the two H2S …

The heme oxygenase/biliverdin reductase (HO/BVR) axis catalyzes the degradation of
heme, but this system and its byproducts, carbon monoxide (CO) and bilirubin, have also …

Carnosine (β-alanyl-l-histidine) has described as a forgotten and enigmatic dipeptide.
Carnosine's enigma is particularly exemplified by its apparent anti-ageing actions; it …

Carnosinase is a dipeptidase found almost exclusively in brain and serum. Its natural
substrate carnosine, present at high concentration in the brain, has been proposed as an …

Neurodegeneration is frequently associated with damage by free radicals. However,
increases in reactive oxygen and nitrogen species, which may ultimately lead to neuronal …

Resveratrol (3, 4′, 5-trans-trihydroxystilbene) and other hydroxystilbenes exhibit in vitro
antioxidant as well as prooxidant effects. The antioxidant properties are assumed to enable …

Stress or heat-shock proteins (HSPs) are highly conserved proteins present in cells of both
prokaryotes and eukaryotes, providing them with protection from cellular and environmental …

Resveratrol, a naturally occurring polyphenol, exhibits antioxidant, antiaging, and anticancer
activity. Resveratrol has also been shown to inhibit tumor initiation, promotion, and …