In the pathogenesis of bone destruction associated with rheumatoid arthritis, the synovium is
a site of active interplay between immune and bone cells. The interaction between T cells …

Osteoclasts are unique, multinucleated giant cells that decalcify and degrade the bone
matrix. They originate from hematopoietic cells and their differentiation is dependent on a …

Osteoclasts are acid-secreting polykaryons that have high energy demands and contain
abundant mitochondria. How mitochondrial biogenesis is integrated with osteoclast …

Bone remodeling is required for healthy calcium homeostasis and for repair of damage
occurring with stress and age. Osteoclasts resorb bone and osteoblasts form bone. These …

Osteoclasts are the cells that degrade bone to initiate normal bone remodeling and mediate
bone loss in pathologic conditions by increasing their resorptive activity. They are derived …

Introduction The interaction between the immune and skeletal systems has long been
acknowledged, but investigation into rheumatoid arthritis (RA) as well as the various bone …

An important function of receptors that signal through immunoreceptor tyrosine-based
activation motifs (ITAMs) is to regulate signaling by heterologous receptors. This review …

TLRs have been implicated in promoting osteoclast-mediated bone resorption associated
with inflammatory conditions. TLRs also activate homeostatic mechanisms that suppress …

Osteoimmunology is an emerging field of research dedicated to the investigation of the
interactions between the immune and skeletal systems. These interactions are not only …

Osteoclasts are multinucleated cells that are formed by the fusion of mononuclear
osteoclasts, which is an essential process in bone resorption leading to bone remodeling …